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A Human Cellular Protein Activity (OF-1), Which Binds Herpes Simplex Virus Type 1 Origin, Contains the Ku70/Ku80 Heterodimer

Lauren B. Murata,^1, Mark S. Dodson,^2, and Jennifer D. Hall^1,2*

Departments of Molecular and Cellular Biology,¹ Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721²

Received 8 January 2004/ Accepted 27 February 2004

In an effort to identify host proteins involved in herpes simplex virus type 1 replication, monkey and human cellular protein activities (called OF-1) that bind the viral replication origin, oriS, have been described. We show by mass spectrometry that the DNA-binding component of human OF-1 contains Ku70 and Ku80 proteins.

Present address: Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721.

Present address: Aventis Combinatorial Technologies Center, Tucson, AZ 85737.

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