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Journal of Virology, July 2004, p. 7839-7842, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7839-7842.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Human Cellular Protein Activity (OF-1), Which Binds Herpes Simplex Virus Type 1 Origin, Contains the Ku70/Ku80 Heterodimer

Lauren B. Murata,1,{dagger} Mark S. Dodson,2,{ddagger} and Jennifer D. Hall1,2*

Departments of Molecular and Cellular Biology,1 Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 857212

Received 8 January 2004/ Accepted 27 February 2004

In an effort to identify host proteins involved in herpes simplex virus type 1 replication, monkey and human cellular protein activities (called OF-1) that bind the viral replication origin, oriS, have been described. We show by mass spectrometry that the DNA-binding component of human OF-1 contains Ku70 and Ku80 proteins.

* Corresponding author. Mailing address: Department of Molecular and Cellular Biology, University of Arizona, P.O. Box 210106, Tucson, AZ 85721. Phone: (520) 621-7525. Fax: (520) 621-3709. E-mail: jdhall{at}u.arizona.edu.

{dagger} Present address: Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721.

{ddagger} Present address: Aventis Combinatorial Technologies Center, Tucson, AZ 85737.

Journal of Virology, July 2004, p. 7839-7842, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7839-7842.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Balliet, J. W., Min, J. C., Cabatingan, M. S., Schaffer, P. A. (2005). Site-Directed Mutagenesis of Large DNA Palindromes: Construction and In Vitro Characterization of Herpes Simplex Virus Type 1 Mutants Containing Point Mutations That Eliminate the oriL or oriS Initiation Function. J. Virol. 79: 12783-12797 [Abstract] [Full Text]  
  • Sibani, S., Price, G. B., Zannis-Hadjopoulos, M. (2005). Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cells. J. Cell Sci. 118: 3247-3261 [Abstract] [Full Text]  


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