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Journal of Virology, July 2004, p. 7828-7832, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7828-7832.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia

Chandran Ramakrishna,1,2 Cornelia C. Bergmann,1,2 Kathryn V. Holmes,3 and Stephen A. Stohlman1,2,4*

Departments of Neurology,1 Pathology,2 Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033,4 Department of Microbiology, University of Colorado Health Science Center, Denver, Colorado 802623

Received 23 December 2003/ Accepted 9 March 2004

Detection of the mouse hepatitis virus receptor within the central nervous system (CNS) has been elusive. Receptor expression on microglia was reduced during acute infection and restored following immune-mediated virus control. Receptor down regulation was independent of neutrophils, NK cells, gamma interferon, or perforin. Infection of mice devoid of distinct inflammatory cells revealed CD4+ T cells as the major cell type influencing receptor expression by microglia. In addition to demonstrating receptor expression on CNS resident cells, these data suggest that transient receptor down regulation on microglia aids in establishing persistence in the CNS by assisting virus infection of other glial cell types.

* Corresponding author. Mailing address: Department of Neurology, Keck School of Medicine, University of Southern California, MCH 142, Los Angeles, CA 90033. Phone: (323) 442-1063. Fax: (323) 225-2369. E-mail: stohlman{at}usc.edu.

Journal of Virology, July 2004, p. 7828-7832, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7828-7832.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Copyright © 2004 by the American Society for Microbiology. All rights reserved.