This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCormack, J. C.
Right arrow Articles by Simon, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCormack, J. C.
Right arrow Articles by Simon, A. E.

 Previous Article  |  Next Article 

Journal of Virology, July 2004, p. 7813-7817, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7813-7817.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Biased Hypermutagenesis Associated with Mutations in an Untranslated Hairpin of an RNA Virus

John C. McCormack and Anne E. Simon*

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742

Received 16 February 2004/ Accepted 3 April 2004

The mutation frequency of Turnip crinkle virus can increase 12-fold without inducing error catastrophe. Lesions in a hairpin repressor frequently reverted and led to second-site alterations biased for specific mutations. These results suggest that the hairpin may also function as an RNA chaperone to properly fold the RNA-dependent RNA polymerase.

* Corresponding author. Mailing address: Department of Cell Biology and Molecular Genetics, 1109 Microbiology Building, University of Maryland, College Park, MD 20742. Phone: (301) 405-8975. Fax: (301) 314-7930. E-mail: Anne_Simon{at}umail.umd.edu.

Journal of Virology, July 2004, p. 7813-7817, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7813-7817.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Guo, R., Lin, W., Zhang, J., Simon, A. E., Kushner, D. B. (2009). Structural Plasticity and Rapid Evolution in a Viral RNA Revealed by In Vivo Genetic Selection. J. Virol. 83: 927-939 [Abstract] [Full Text]  
  • Stupina, V. A., Meskauskas, A., McCormack, J. C., Yingling, Y. G., Shapiro, B. A., Dinman, J. D., Simon, A. E. (2008). The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits. RNA 14: 2379-2393 [Abstract] [Full Text]  
  • Seemann, S. E., Gorodkin, J., Backofen, R. (2008). Unifying evolutionary and thermodynamic information for RNA folding of multiple alignments. Nucleic Acids Res 36: 6355-6362 [Abstract] [Full Text]  
  • McCormack, J. C., Yuan, X., Yingling, Y. G., Kasprzak, W., Zamora, R. E., Shapiro, B. A., Simon, A. E. (2008). Structural Domains within the 3' Untranslated Region of Turnip Crinkle Virus. J. Virol. 82: 8706-8720 [Abstract] [Full Text]  
  • Zhang, J., Zhang, G., Guo, R., Shapiro, B. A., Simon, A. E. (2006). A pseudoknot in a preactive form of a viral RNA is part of a structural switch activating minus-strand synthesis.. J. Virol. 80: 9181-9191 [Abstract] [Full Text]  
  • ZHANG, G., ZHANG, J., GEORGE, A. T., BAUMSTARK, T., SIMON, A. E. (2006). Conformational changes involved in initiation of minus-strand synthesis of a virus-associated RNA. RNA 12: 147-162 [Abstract] [Full Text]  
  • Sun, X., Zhang, G., Simon, A. E. (2005). Short Internal Sequences Involved in Replication and Virion Accumulation in a Subviral RNA of Turnip Crinkle Virus. J. Virol. 79: 512-524 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»