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Journal of Virology, July 2004, p. 7518-7522, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7518-7522.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Direct Evidence for Natural Transmission of Small-Ruminant Lentiviruses of Subtype A4 from Goats to Sheep and Vice Versa

Cyril Shah,1 Jon B. Huder,1 Jürg Böni,1 Marietta Schönmann,2 Janine Mühlherr,2 Hans Lutz,3 and Jörg Schüpbach1*

Swiss National Center for Retroviruses,1 Clinical Laboratory, Faculty of Veterinary Medicine, University of Zurich, Zurich,3 Extension and Health Service for Small Ruminants, Herzogenbuchsee, Switzerland2

Received 27 November 2003/ Accepted 12 March 2004

Small-ruminant lentiviruses (SRLV), which include the caprine arthritis-encephalitis and the maedi-visna virus, cause persistent inflammatory infections in goats and sheep. SRLV are mainly transmitted from mother to offspring through milk. Transmission after prolonged contact between adult animals has also been observed. The observation that certain SRLV subtypes are found in both goats and sheep suggests that interspecies transmission has occurred on several occasions in the past. We investigated seropositive goats and sheep that were kept together in small mixed herds. Phylogenetic analysis of long proviral sequences in gag and pol, combined with epidemiologic information, demonstrated natural sheep-to-goat transmission of the recently identified SRLV subtype A4 in two instances and goat-to-sheep transmission of the same subtype in one instance. In a further mixed cluster, the direction of the interspecies transmission could not be determined. These findings present for the first time direct evidence that natural interspecies transmission of SRLV is ongoing in both directions. The findings are of relevance to virus eradication programs in both species.

* Corresponding author. Mailing address: Swiss National Center for Retroviruses, University of Zurich, Gloriastrasse 30, CH-8028 Zurich, Switzerland. Phone: 41 1 634 3803. Fax: 41 1 634 4965. E-mail: jschupb{at}immv.unizh.ch.

Journal of Virology, July 2004, p. 7518-7522, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7518-7522.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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