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Journal of Virology, July 2004, p. 7279-7283, Vol. 78, No. 13
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.13.7279-7283.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human Immunodeficiency Virus Type 1 (HIV-1) Diversity at Time of Infection Is Not Restricted to Certain Risk Groups or Specific HIV-1 Subtypes

Divisions of Human Biology,¹ Public Health Sciences, Fred Hutchinson Cancer Research Center,⁵ Department of Medicine, University of Washington, Seattle, Washington,² Department of Public Health, San Francisco ,³ Harbor-UCLA Research and Education Institute, David Geffen School of Medicine at UCLA, Torrance, California⁴

Received 30 December 2003/ Accepted 18 March 2004

African women frequently acquire several genetically distinct human immunodeficiency virus type 1 (HIV-1) variants from a heterosexual partner, whereas the acquisition of multiple variants appears to be rare in men. To determine whether newly infected individuals in other risk groups acquire genetically diverse viruses, we examined the viral envelope sequences in plasma samples from 13 women and 4 men from the United States infected with subtype B viruses and 10 men from Kenya infected with non-subtype B viruses. HIV-1 envelope sequences differed by more than 2% in three U.S. women, one U.S. man, and one Kenyan man near the time of seroconversion. These findings suggest that early HIV-1 genetic diversity is not exclusive to women from Africa or to infection with any particular HIV-1 subtype.

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