This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sagar, M.
Right arrow Articles by Overbaugh, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sagar, M.
Right arrow Articles by Overbaugh, J.

 Previous Article  |  Next Article 

Journal of Virology, July 2004, p. 7279-7283, Vol. 78, No. 13
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.13.7279-7283.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human Immunodeficiency Virus Type 1 (HIV-1) Diversity at Time of Infection Is Not Restricted to Certain Risk Groups or Specific HIV-1 Subtypes

Manish Sagar,1,2 Erin Kirkegaard,1 E. Michelle Long,1 Connie Celum,2 Susan Buchbinder,3 Eric S. Daar,4 and Julie Overbaugh1,5*

Divisions of Human Biology,1 Public Health Sciences, Fred Hutchinson Cancer Research Center,5 Department of Medicine, University of Washington, Seattle, Washington,2 Department of Public Health, San Francisco ,3 Harbor-UCLA Research and Education Institute, David Geffen School of Medicine at UCLA, Torrance, California4

Received 30 December 2003/ Accepted 18 March 2004

African women frequently acquire several genetically distinct human immunodeficiency virus type 1 (HIV-1) variants from a heterosexual partner, whereas the acquisition of multiple variants appears to be rare in men. To determine whether newly infected individuals in other risk groups acquire genetically diverse viruses, we examined the viral envelope sequences in plasma samples from 13 women and 4 men from the United States infected with subtype B viruses and 10 men from Kenya infected with non-subtype B viruses. HIV-1 envelope sequences differed by more than 2% in three U.S. women, one U.S. man, and one Kenyan man near the time of seroconversion. These findings suggest that early HIV-1 genetic diversity is not exclusive to women from Africa or to infection with any particular HIV-1 subtype.

* Corresponding author. Mailing address: Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, C3-168, Seattle, WA 98109. Phone: (206) 667-3524. Fax: (206) 667-1535. E-mail: joverbau{at}fhcrc.org.

Journal of Virology, July 2004, p. 7279-7283, Vol. 78, No. 13
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.13.7279-7283.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Blish, C. A., Jalalian-Lechak, Z., Rainwater, S., Nguyen, M.-A., Dogan, O. C., Overbaugh, J. (2009). Cross-Subtype Neutralization Sensitivity despite Monoclonal Antibody Resistance among Early Subtype A, C, and D Envelope Variants of Human Immunodeficiency Virus Type 1. J. Virol. 83: 7783-7788 [Abstract] [Full Text]  
  • Keele, B. F., Li, H., Learn, G. H., Hraber, P., Giorgi, E. E., Grayson, T., Sun, C., Chen, Y., Yeh, W. W., Letvin, N. L., Mascola, J. R., Nabel, G. J., Haynes, B. F., Bhattacharya, T., Perelson, A. S., Korber, B. T., Hahn, B. H., Shaw, G. M. (2009). Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1. JEM 206: 1117-1134 [Abstract] [Full Text]  
  • Abrahams, M.-R., Anderson, J. A., Giorgi, E. E., Seoighe, C., Mlisana, K., Ping, L.-H., Athreya, G. S., Treurnicht, F. K., Keele, B. F., Wood, N., Salazar-Gonzalez, J. F., Bhattacharya, T., Chu, H., Hoffman, I., Galvin, S., Mapanje, C., Kazembe, P., Thebus, R., Fiscus, S., Hide, W., Cohen, M. S., Karim, S. A., Haynes, B. F., Shaw, G. M., Hahn, B. H., Korber, B. T., Swanstrom, R., Williamson, C., for the CAPRISA Acute Infection Study Team and the, (2009). Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants. J. Virol. 83: 3556-3567 [Abstract] [Full Text]  
  • Coetzer, M., Nedellec, R., Salkowitz, J., McLaughlin, S., Liu, Y., Heath, L., Mullins, J. I., Mosier, D. E. (2008). Evolution of CCR5 Use before and during Coreceptor Switching. J. Virol. 82: 11758-11766 [Abstract] [Full Text]  
  • Ceballos, A., Andreani, G., Ripamonti, C., Dilernia, D., Mendez, R., Rabinovich, R. D., Cardenas, P. C., Zala, C., Cahn, P., Scarlatti, G., Peralta, L. M. (2008). Lack of viral selection in human immunodeficiency virus type 1 mother-to-child transmission with primary infection during late pregnancy and/or breastfeeding. J. Gen. Virol. 89: 2773-2782 [Abstract] [Full Text]  
  • Keele, B. F., Giorgi, E. E., Salazar-Gonzalez, J. F., Decker, J. M., Pham, K. T., Salazar, M. G., Sun, C., Grayson, T., Wang, S., Li, H., Wei, X., Jiang, C., Kirchherr, J. L., Gao, F., Anderson, J. A., Ping, L.-H., Swanstrom, R., Tomaras, G. D., Blattner, W. A., Goepfert, P. A., Kilby, J. M., Saag, M. S., Delwart, E. L., Busch, M. P., Cohen, M. S., Montefiori, D. C., Haynes, B. F., Gaschen, B., Athreya, G. S., Lee, H. Y., Wood, N., Seoighe, C., Perelson, A. S., Bhattacharya, T., Korber, B. T., Hahn, B. H., Shaw, G. M. (2008). Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc. Natl. Acad. Sci. USA 105: 7552-7557 [Abstract] [Full Text]  
  • Salazar-Gonzalez, J. F., Bailes, E., Pham, K. T., Salazar, M. G., Guffey, M. B., Keele, B. F., Derdeyn, C. A., Farmer, P., Hunter, E., Allen, S., Manigart, O., Mulenga, J., Anderson, J. A., Swanstrom, R., Haynes, B. F., Athreya, G. S., Korber, B. T. M., Sharp, P. M., Shaw, G. M., Hahn, B. H. (2008). Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing. J. Virol. 82: 3952-3970 [Abstract] [Full Text]  
  • Joos, B., Trkola, A., Fischer, M., Kuster, H., Rusert, P., Leemann, C., Boni, J., Oxenius, A., Price, D. A., Phillips, R. E., Wong, J. K., Hirschel, B., Weber, R., Gunthard, H. F., the Swiss HIV Cohort Study, (2005). Low Human Immunodeficiency Virus Envelope Diversity Correlates with Low In Vitro Replication Capacity and Predicts Spontaneous Control of Plasma Viremia after Treatment Interruptions. J. Virol. 79: 9026-9037 [Abstract] [Full Text]  
  • Chohan, B., Lang, D., Sagar, M., Korber, B., Lavreys, L., Richardson, B., Overbaugh, J. (2005). Selection for Human Immunodeficiency Virus Type 1 Envelope Glycosylation Variants with Shorter V1-V2 Loop Sequences Occurs during Transmission of Certain Genetic Subtypes and May Impact Viral RNA Levels. J. Virol. 79: 6528-6531 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»