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Journal of Virology, July 2004, p. 7248-7256, Vol. 78, No. 13
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.13.7248-7256.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Mitotic Chromosome-Binding Activity of Latency-Associated Nuclear Antigen 1 Is Required for DNA Replication from Terminal Repeat Sequence of Kaposi's Sarcoma-Associated Herpesvirus

Chunghun Lim, Changtaek Choi, and Joonho Choe*

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Received 30 November 2003/ Accepted 1 March 2004

Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated in the persistence of the viral genome during latent infection. It has been suggested that LANA1 tethers the viral genome to the host chromosome and also participates actively in DNA replication from the terminal repeat of KSHV. Here we show by mutational analysis that the mitotic chromosome-binding activity of LANA1 is tightly coupled to its replication activity. Thus, KSHV appears to have evolved a unique tactic for its stable maintenance.

* Correpsonding author. Mailing address: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Guseong-Dong, Yuseong-Gu, Daejeon 305-701, South Korea. Phone: 82-42-869-2630. Fax: 82-42-869-5630. E-mail: jchoe{at}kaist.ac.kr.

Journal of Virology, July 2004, p. 7248-7256, Vol. 78, No. 13
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.13.7248-7256.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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