This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yokota, S.-i.
Right arrow Articles by Fujii, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yokota, S.-i.
Right arrow Articles by Fujii, N.

 Previous Article  |  Next Article 

Journal of Virology, June 2004, p. 6282-6286, Vol. 78, No. 12
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.12.6282-6286.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway

Shin-ichi Yokota,1 Noriko Yokosawa,1 Tamaki Okabayashi,1 Tatsuo Suzutani,2 Shunsuke Miura,3 Kowichi Jimbow,3 and Nobuhiro Fujii1*

Department of Microbiology,1 Department of Dermatology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556,3 Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan2

Received 26 November 2003/ Accepted 5 February 2004

We showed previously that herpes simplex virus type 1 (HSV-1) suppresses the interferon (IFN) signaling pathway during the early infection stage in the human amnion cell line FL. HSV-1 inhibits the IFN-induced phosphorylation of Janus kinases (JAK) in infected FL cells. In the present study, we showed that the suppressor of cytokine signaling-3 (SOCS3), a host negative regulator of the JAK/STAT pathway, is rapidly induced in FL cells after HSV-1 infection. Maximal levels of SOCS3 protein were detected at around 1 to 2 h after infection. This is consistent with the occurrence of HSV-1-mediated inhibition of IFN-induced JAK phosphorylation. The HSV-1 wild-type strain VR3 induced SOCS3 more efficiently than did mutants that are defective in UL41 or UL13 and that are hyperresponsive to IFN. Induction of the IRF-7 protein and transcriptional activation of IFN-{alpha}4, which occur in a JAK/STAT pathway-dependent manner, were poorly induced by VR3 but efficiently induced by the mutant viruses. In contrast, phosphorylation of IRF-3 and transcriptional activation of IFN-ß, which are JAK/STAT pathway-independent process, were equally well induced by the wild-type strain and the mutants. In conclusion, the SOCS3 protein appears to be mainly responsible for the suppression of IFN signaling and IFN production that occurs during HSV-1 infection.

* Corresponding author. Mailing address: Department of Microbiology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556, Hokkaido, Japan. Phone: 81-11-611-2111. Fax: 81-11-612-5861. E-mail: fujii{at}sapmed.ac.jp.

Journal of Virology, June 2004, p. 6282-6286, Vol. 78, No. 12
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.12.6282-6286.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Frey, K. G., Ahmed, C. M. I., Dabelic, R., Jager, L. D., Noon-Song, E. N., Haider, S. M., Johnson, H. M., Bigley, N. J. (2009). HSV-1-Induced SOCS-1 Expression in Keratinocytes: Use of a SOCS-1 Antagonist to Block a Novel Mechanism of Viral Immune Evasion. J. Immunol. 183: 1253-1262 [Abstract] [Full Text]  
  • Pothlichet, J., Chignard, M., Si-Tahar, M. (2008). Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway. J. Immunol. 180: 2034-2038 [Abstract] [Full Text]  
  • Randall, R. E., Goodbourn, S. (2008). Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol. 89: 1-47 [Abstract] [Full Text]  
  • Hochreiter, R., Ptaschinski, C., Kunkel, S. L., Rochford, R. (2007). Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturation. J. Gen. Virol. 88: 1896-1905 [Abstract] [Full Text]  
  • Jaworska, J., Gravel, A., Fink, K., Grandvaux, N., Flamand, L. (2007). Inhibition of Transcription of the Beta Interferon Gene by the Human Herpesvirus 6 Immediate-Early 1 Protein. J. Virol. 81: 5737-5748 [Abstract] [Full Text]  
  • Barreca, C., O'Hare, P. (2006). Characterization of a potent refractory state and persistence of herpes simplex virus 1 in cell culture.. J. Virol. 80: 9171-9180 [Abstract] [Full Text]  
  • Pasieka, T. J., Baas, T., Carter, V. S., Proll, S. C., Katze, M. G., Leib, D. A. (2006). Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response.. J. Virol. 80: 7600-7612 [Abstract] [Full Text]  
  • Brukman, A., Enquist, L. W. (2006). Suppression of the interferon-mediated innate immune response by pseudorabies virus.. J. Virol. 80: 6345-6356 [Abstract] [Full Text]  
  • Sobol, P. T., Mossman, K. L. (2006). ICP0 Prevents RNase L-Independent rRNA Cleavage in Herpes Simplex Virus Type 1-Infected Cells. J. Virol. 80: 218-225 [Abstract] [Full Text]  
  • Yao, Z. Q., Waggoner, S. N., Cruise, M. W., Hall, C., Xie, X., Oldach, D. W., Hahn, Y. S. (2005). SOCS1 and SOCS3 Are Targeted by Hepatitis C Virus Core/gC1qR Ligation To Inhibit T-Cell Function. J. Virol. 79: 15417-15429 [Abstract] [Full Text]  
  • Austin, B. A., James, C., Silverman, R. H., Carr, D. J. J. (2005). Critical Role for the Oligoadenylate Synthetase/RNase L Pathway in Response to IFN-{beta} during Acute Ocular Herpes Simplex Virus Type 1 Infection. J. Immunol. 175: 1100-1106 [Abstract] [Full Text]  
  • Guo, J.-T., Hayashi, J., Seeger, C. (2005). West Nile Virus Inhibits the Signal Transduction Pathway of Alpha Interferon. J. Virol. 79: 1343-1350 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»