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Journal of Virology, June 2004, p. 6061-6066, Vol. 78, No. 11
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.11.6061-6066.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Reverse Genetic Analysis of the Transcription Regulatory Sequence of the Coronavirus Transmissible Gastroenteritis Virus

Kristopher M. Curtis,1 Boyd Yount,2 Amy C. Sims,2 and Ralph S. Baric1,2*

Department of Microbiology and Immunology, School of Medicine,1 Department of Epidemiology, Program of Infectious Diseases, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-74352

Received 18 September 2003/ Accepted 27 January 2004

Coronavirus discontinuous transcription uses a highly conserved sequence (CS) in the joining of leader and body RNAs. Using a full-length infectious construct of transmissable gastroenteritis virus, the present study demonstrates that subgenomic transcription is heavily influenced by upstream flanking sequences and supports a mechanism of transcription attenuation that is regulated in part by a larger domain composed of primarily upstream flanking sequences which select appropriately positioned CS elements for synthesis of subgenomic RNAs.

* Corresponding author. Mailing address: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435. Phone: (919) 966-3895. Fax: (919) 966-2089. E-mail: rbaric{at}email.unc.edu.

Journal of Virology, June 2004, p. 6061-6066, Vol. 78, No. 11
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.11.6061-6066.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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