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Journal of Virology, June 2004, p. 6055-6060, Vol. 78, No. 11
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.11.6055-6060.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency

Kathy A. Green,* Cory L. Ahonen, W. James Cook,{dagger} and William R. Green

Department of Microbiology and Immunology, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756

Received 8 October 2003/ Accepted 14 January 2004

LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, 1 Medical Center Dr., Dartmouth Medical School, Lebanon, NH 03750. Phone: (603) 650-8607. Fax: (603) 650-6223. E-mail: Kathy.A.Green{at}dartmouth.edu.

{dagger} Present address: GlycoFi, Inc., Lebanon, NH 03766.

Journal of Virology, June 2004, p. 6055-6060, Vol. 78, No. 11
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.11.6055-6060.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Green, K. A., Okazaki, T., Honjo, T., Cook, W. J., Green, W. R. (2008). The Programmed Death-1 and Interleukin-10 Pathways Play a Down-Modulatory Role in LP-BM5 Retrovirus-Induced Murine Immunodeficiency Syndrome. J. Virol. 82: 2456-2469 [Abstract] [Full Text]  
  • Li, W., Green, W. R. (2006). The Role of CD4 T Cells in the Pathogenesis of Murine AIDS.. J. Virol. 80: 5777-5789 [Abstract] [Full Text]  
  • Gaur, A., Green, W. R. (2005). Role of a Cytotoxic-T-Lymphocyte Epitope-Defined, Alternative gag Open Reading Frame in the Pathogenesis of a Murine Retrovirus-Induced Immunodeficiency Syndrome. J. Virol. 79: 4308-4315 [Abstract] [Full Text]  


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