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Journal of Virology, June 2004, p. 6043-6047, Vol. 78, No. 11
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.11.6043-6047.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Recombinant Sendai Virus Expressing the G Glycoprotein of Respiratory Syncytial Virus (RSV) Elicits Immune Protection against RSV

Toru Takimoto,1,2 Julia L. Hurwitz,3,4 Chris Coleclough,3,4 Cecilia Prouser,2 Sateesh Krishnamurthy,1,2 Xiaoyan Zhan,2 Kelli Boyd,5 Ruth A. Scroggs,1,2 Brita Brown,3 Yoshiyuki Nagai,6 Allen Portner,1,2,4 and Karen S. Slobod2,7*

Division of Virology,1 Department of Infectious Diseases,2 Department of Immunology,3 Animal Resources Center, St. Jude Children's Research Hospital,5 Departments of Pathology,4 Pediatrics, University of Tennessee, Memphis, Tennessee,7 Toyama Institute of Health, Toyama, Japan6

Received 13 August 2003/ Accepted 27 January 2004

Although RSV causes serious pediatric respiratory disease, an effective vaccine does not exist. To capture the strengths of a live virus vaccine, we have used the murine parainfluenza virus type 1 (Sendai virus [SV]) as a xenogeneic vector to deliver the G glycoprotein of RSV. It was previously shown (J. L. Hurwitz, K. F. Soike, M. Y. Sangster, A. Portner, R. E. Sealy, D. H. Dawson, and C. Coleclough, Vaccine 15:533-540, 1997) that intranasal SV protected African green monkeys from challenge with the related human parainfluenza virus type 1 (hPIV1), and SV has advanced to clinical trials as a vaccine for hPIV1 (K. S. Slobod, J. L. Shenep, J. Lujan-Zilbermann, K. Allison, B. Brown, R. A. Scroggs, A. Portner, C. Coleclough, and J. L. Hurwitz, Vaccine, in press). Recombinant SV expressing RSV G glycoprotein was prepared by using reverse genetics, and intranasal inoculation of cotton rats elicited RSV-specific antibody and elicited protection from RSV challenge. RSV G-recombinant SV is thus a promising live virus vaccine candidate for RSV.

* Corresponding author. Mailing address: St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105. Phone: (901) 495-2650. Fax: (901) 495-3099. E-mail: karen.slobod{at}stjude.org.

Journal of Virology, June 2004, p. 6043-6047, Vol. 78, No. 11
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.11.6043-6047.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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