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Journal of Virology, May 2003, p. 5535-5539, Vol. 77, No. 9
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.9.5535-5539.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Sphingosine Kinase-Dependent Migration of Immature Dendritic Cells in Response to Neurotoxic Prion Protein Fragment

Division of General Internal Medicine,¹ Division of Gastroenterology, Department of Internal Medicine, University of Innsbruck, A-6020 Innsbruck, Austria²

Received 9 October 2002/ Accepted 5 February 2003

The concept that circulating dendritic cells mediate neuroinvasion in transmissible spongiform encephalopathies received strong support from recent observations that prion protein is expressed in myeloid dendritic cells. We observed that prion protein fragment 106-126 is a chemoattractant for monocyte-derived immature but not mature dendritic cells. Signaling events in chemotaxis involved enzymes downstream of G_q protein and were inhibited by blockade of sphingosine kinase, suggesting transactivation of sphingosine-1-phosphate-dependent cell motility by prion protein.

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