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Journal of Virology, May 2003, p. 5503-5506, Vol. 77, No. 9
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.9.5503-5506.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Hepatitis B Virus-Mediated Changes of Apolipoprotein mRNA Abundance in Cultured Hepatoma Cells

Pamela A. Norton,* Qiaoke Gong, Anand S. Mehta, Xuanyong Lu, and Timothy M. Block

Jefferson Center for Biomedical Research and Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Doylestown, Pennsylvania

Received 4 September 2002/ Accepted 3 February 2003

An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.

* Corresponding author. Mailing address: Jefferson Center for Biomedical Research, 700 E. Butler Ave., Doylestown, PA 18901. Phone: (215) 489-4903. Fax: (215) 489-4920. E-mail: pamela.norton{at}mail.tju.edu.

Journal of Virology, May 2003, p. 5503-5506, Vol. 77, No. 9
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.9.5503-5506.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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