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Journal of Virology, May 2003, p. 5493-5498, Vol. 77, No. 9
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.9.5493-5498.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interleukin-1 Inhibits Hepatitis C Virus Subgenomic RNA Replication by Activation of Extracellular Regulated Kinase Pathway

Haizhen Zhu and Chen Liu*

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610-0275

Received 17 December 2002/ Accepted 12 February 2003

Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some studies have demonstrated that IL-1 production was impaired in patients with chronic infections of hepatitis C virus (HCV), implying that IL-1 may play a role in viral clearance. Using an HCV subgenomic replicon cell line, we demonstrate that IL-1 can effectively inhibit HCV subgenomic RNA replication and viral protein expression, suggesting that IL-1 has direct antiviral activity. The inhibitory effect is associated with the extracellular regulatory kinase (ERK) activation. In addition, we also show that IL-1 can induce one of the interferon-stimulated genes (ISGs), 1-8U, which exhibits antiviral activity. However, it has no effect on the other ISG, 6-16, suggesting that IL-1 induces novel antiviral pathways within a cell.

* Corresponding author. Mailing address: Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275. Phone: (352) 392-2886. Fax: (352) 846-1742. E-mail: liu{at}pathology.ufl.edu.

Journal of Virology, May 2003, p. 5493-5498, Vol. 77, No. 9
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.9.5493-5498.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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