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Journal of Virology, April 2003, p. 5014-5016, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.5014-5016.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Vigorous but Short-Term Gamma Interferon T-Cell Responses against a Dominant HLA-A*02-Restricted Measles Virus Epitope in Patients with Measles

Assan Jaye,1* Carla A. Herberts,2,{dagger} Sabelle Jallow,1 Sowsan Atabani,1 Michel R. Klein,1,{ddagger} Peter Hoogerhout,2 Michael Kidd,1 Cécile A. C. M. van Els,2 and Hilton C. Whittle1

Medical Research Council Laboratories (MRC), Banjul, The Gambia,1 Laboratory of Vaccine Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands2

Received 31 October 2002/ Accepted 28 January 2003

The absolute and relative abundance of major histocompatibility complex class I-presented viral epitopes is important in the induction and maintenance of antiviral cytotoxic-T-lymphocyte (CTL) responses. We demonstrate that the supra-abundant HLA-A*0201-restricted peptide KLWESPQEI of the measles virus nonstructural C protein induces strong gamma interferon CD8+-T-cell responses in children with acute measles. However, longitudinal analysis indicates that these responses are only short-lived. Thus, some viral epitopes that can be immunodominant during primary infection may fail to establish memory CTL responses.

* Corresponding author: Mailing address: MRC Laboratories, Fajara, P.O. Box 273, Banjul, The Gambia. Phone: (220) 495442. Fax: (220) 496513 or (220) 495919. E-mail: ajaye{at}mrc.gm.

{dagger} Present address: Department of Tumor Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

{ddagger} Present address: Department of Immunohaematology and Blood Transfusion, Leiden Medical University Center, 2333 ZA Leiden, The Netherlands.

Journal of Virology, April 2003, p. 5014-5016, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.5014-5016.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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