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Journal of Virology, April 2003, p. 4992-4999, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.4992-4999.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Human Herpesvirus 6 Variant A Glycoprotein H-Glycoprotein L-Glycoprotein Q Complex Associates with Human CD46

Yasuko Mori,1* Xuwei Yang,1 Pilailuk Akkapaiboon,1 Toshiomi Okuno,2 and Koichi Yamanishi1

Department of Microbiology, Osaka University Medical School, Suita, Osaka 565-0871,1 Department of Microbiology, Hyogo Medical College, Nishinomiya 663-8501, Japan2

Received 8 October 2002/ Accepted 14 January 2003

Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46.

* Corresponding author. Mailing address: Department of Microbiology, Osaka University Medical School C1, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan. Fax: 81-6-6879-3329. Phone: 81-6-6879-3321. E-mail: ymori{at}micro.med.osaka-u.ac.jp.

Journal of Virology, April 2003, p. 4992-4999, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.4992-4999.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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