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Journal of Virology, April 2003, p. 4960-4964, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.4960-4964.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Adenovirus Dodecahedron Allows Large Multimeric Protein Transduction in Human Cells

P. Fender,1* G. Schoehn,1,2 J. Foucaud-Gamen,3 E. Gout,1 A. Garcel,1 E. Drouet,3 and J. Chroboczek1

Institut de Biologie Structurale,1 Laboratoire Européen de Biologie Moléculaire, 38027 Grenoble,2 Faculté de Pharmacie, Domaine de la Merci, 38 La Tronche, France3

Received 11 November 2002/ Accepted 14 January 2003

Adenovirus dodecahedron is a virus-like particle composed of only two viral proteins of human adenovirus serotype 3 that are responsible for virus attachment and internalization. We show here that this dodecameric particle, devoid of genetic information, efficiently penetrates human cells and can deliver large multimeric proteins such as immunoglobulins.

* Corresponding author. Mailing address: Institut de Biologie Structurale, 41 Rue Jules Horowitz, 38027 Grenoble, France. Phone: 33-4-38-78-96-28. Fax: 33-4-38-78-54-94. E-mail: fender{at}ibs.fr.

Journal of Virology, April 2003, p. 4960-4964, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.4960-4964.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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