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Journal of Virology, April 2003, p. 4588-4596, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.4588-4596.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

Teresa Compton,1* Evelyn A. Kurt-Jones,2 Karl W. Boehme,1 John Belko,2 Eicke Latz,2 Douglas T. Golenbock,2 and Robert W. Finberg2

McArdle Laboratory for Cancer Research, University of Wisconsin—Madison Medical School, Madison, Wisconsin 53706,1 Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 016052

Received 2 October 2002/ Accepted 13 January 2003

Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immuncompromised people. An understanding of how CMV induces and circumvents host immunity is of critical importance in efforts to design effective therapeutics. It was recently discovered that mere cell contact by CMV particles leads to profound modulation of cellular gene expression, including induction of inflammatory cytokines and interferon-stimulated genes characteristic of innate immune detection. These findings suggest that a membrane receptor recognizes a CMV envelope protein(s), leading to innate immune activation. Here, we show that the pattern recognition receptors Toll-like receptor 2 (TLR2) and CD14 recognize CMV virions and trigger inflammatory cytokine production. Induction of inflammatory cytokines is mediated via TLR2-dependent activation of NF-{kappa}B. Since many of the pathological processes associated with CMV disease are facilitated or directly mediated by inflammatory cytokines, identification of the host membrane detection machinery may ultimately lead to improved therapeutics.

* Corresponding author. Mailing address: McArdle Laboratory for Cancer Research, University of Wisconsin—Madison Medical School, Madison, WI 53706. Phone: (608) 262-1474. Fax: (608) 262-2824. E-mail: tcompton{at}wisc.edu.

Journal of Virology, April 2003, p. 4588-4596, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.4588-4596.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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