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Journal of Virology, April 2003, p. 4444-4448, Vol. 77, No. 7
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.7.4444-4448.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Polyprotein Processing Protease of African Swine Fever Virus: Purification and Biochemical Characterization

Daniel Rubio, Alí Alejo, Irene Rodríguez, and María L. Salas*

Centro de Biología Molecular "Severo Ochoa" (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain

Received 13 September 2002/ Accepted 24 December 2002

The purified recombinant African swine fever virus polyprotein processing protease cleaves the two GG-X sites in polyprotein pp62 with the same efficiency. Cleavage at the site that is first recognized in vivo is not a requisite for cleavage at the second site, suggesting the existence of mechanisms that control the ordered processing of the polyprotein during infection.

* Corresponding author. Mailing address: Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. Phone: 34 913978478. Fax: 34 913974799. E-mail: mlsalas{at}cbm.uam.es.

Journal of Virology, April 2003, p. 4444-4448, Vol. 77, No. 7
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.7.4444-4448.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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