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Journal of Virology, April 2003, p. 4383-4388, Vol. 77, No. 7
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.7.4383-4388.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Apoptotic Cells, Including Macrophages, Are Prominent in Theiler's Virus-Induced Inflammatory, Demyelinating Lesions

Brian P. Schlitt,1 Matthew Felrice,1 Mary Lou Jelachich,1 and Howard L. Lipton1,2,3*

Departments of Neurology,1 Microbiology-Immunology,2 Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston and Chicago, and Evanston Hospital, Evanston, Illinois 602013

Received 11 October 2002/ Accepted 2 January 2003

Theiler's murine encephalomyelitis virus (TMEV) persists in the mouse central nervous system principally in macrophages, and infected macrophages in culture undergo apoptosis. We have detected abundant apoptotic cells in perivascular cuffs and inflammatory, demyelinating lesions of SJL mice chronically infected with TMEV. T cells comprised 74% of apoptotic cells, while 8% were macrophages, 0.6% were astrocytes, and ~17% remained unidentified. In situ hybridization revealed viral RNA in ~1% of apoptotic cells.

* Corresponding author. Mailing address: Department of Neurology, Evanston Hospital, 2650 Ridge Ave., Evanston, IL 60201. Phone: (847) 570-2168. Fax: (847) 570-1568. E-mail: hllipton{at}merle.acns.nwu.edu.

Journal of Virology, April 2003, p. 4383-4388, Vol. 77, No. 7
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.7.4383-4388.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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