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Journal of Virology, March 2003, p. 3866-3870, Vol. 77, No. 6
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.6.3866-3870.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Type B Leukemogenic Virus Truncated Superantigen Is Dispensable for T-Cell Lymphomagenesis

Farah Mustafa,1,{dagger} Sanchita Bhadra,1 Dennis Johnston,2 Mary Lozano,1 and Jaquelin P. Dudley1*

Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, the University of Texas at Austin, Austin, Texas 78712,1 Department of Biomathematics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 770302

Received 9 October 2002/ Accepted 20 December 2002

Type B leukemogenic virus (TBLV) is a variant of mouse mammary tumor virus (MMTV) that causes T-cell lymphomas in mice. We have constructed a TBLV-MMTV hybrid, pHYB-TBLV, in which 756 bp of the C3H MMTV long terminal repeat (LTR) was replaced with 438 bp of the TBLV LTR. Intraperitoneal injection of pHYB-TBLV transfectants consistently resulted in T-cell lymphomas in 50% of injected weanling BALB/c mice with an average latency period of 5.7 (± 1.5) months. Transfectants of pHYB-TBLV containing a double-frameshift mutation in the truncated superantigen gene (sag) induced T-cell lymphomas with similar incidences, latency periods, and phenotypes, suggesting that cis-acting elements in the TBLV LTR determine disease specificity.

* Corresponding author. Mailing address: Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 100 W. 24th St., Austin, TX 78705. Phone: (512) 471-8415. Fax: (512) 471-7088. E-mail: jdudley{at}uts.cc.utexas.edu.

{dagger} Present address: Department of Medical Microbiology, Faculty of Medicine and Health Sciences, The United Arab Emirates (UAE) University, Al Ain, United Arab Emirates.

Journal of Virology, March 2003, p. 3866-3870, Vol. 77, No. 6
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.6.3866-3870.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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