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Journal of Virology, March 2003, p. 3846-3850, Vol. 77, No. 6
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.6.3846-3850.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Human Papillomavirus Types 16, 31, and 58 Use Different Endocytosis Pathways To Enter Cells

Latifa Bousarghin,1 Antoine Touzé,1 Pierre-Yves Sizaret,2 and Pierre Coursaget1*

Laboratoire de Virologie Moléculaire, INSERM EMIU 00-10 et USC INRA, Faculté des Sciences Pharmaceutiques,1 Service de Microscopie Electronique Faculté de Médecine, IFR 82 Transposons et Virus, Tours, France2

Received 31 July 2002/ Accepted 17 December 2002

The early steps of the intracellular trafficking of human papillomavirus type 16 (HPV-16), -31, and -58 pseudovirions were studied by investigating the effects of drugs acting at defined points of endocytosis pathways on virus-like particle-mediated pseudoinfection by overexpression of a dominant-negative form of the Eps15 protein to inhibit clathrin-mediated endocytosis and by electron microscopy. The results obtained suggested the involvement of clathrin-mediated endocytosis in HPV-16 and HPV-58 entry and caveola-mediated endocytosis in HPV-31 entry.

* Corresponding author. Mailing address: Laboratoire de Virologie Moléculaire, Faculté des Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France. Phone: 33 2 47 36 72 56. Fax: 33 2 47 36 71 88. E-mail: coursaget{at}univ-tours.fr.

Journal of Virology, March 2003, p. 3846-3850, Vol. 77, No. 6
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.6.3846-3850.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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