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Human Papillomavirus Types 16, 31, and 58 Use Different Endocytosis Pathways To Enter Cells

Laboratoire de Virologie Moléculaire, INSERM EMIU 00-10 et USC INRA, Faculté des Sciences Pharmaceutiques,¹ Service de Microscopie Electronique Faculté de Médecine, IFR 82 Transposons et Virus, Tours, France²

Received 31 July 2002/ Accepted 17 December 2002

The early steps of the intracellular trafficking of human papillomavirus type 16 (HPV-16), -31, and -58 pseudovirions were studied by investigating the effects of drugs acting at defined points of endocytosis pathways on virus-like particle-mediated pseudoinfection by overexpression of a dominant-negative form of the Eps15 protein to inhibit clathrin-mediated endocytosis and by electron microscopy. The results obtained suggested the involvement of clathrin-mediated endocytosis in HPV-16 and HPV-58 entry and caveola-mediated endocytosis in HPV-31 entry.

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