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Journal of Virology, March 2003, p. 3307-3311, Vol. 77, No. 5
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.5.3307-3311.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Entry of Herpes Simplex Virus Type 1 into Primary Sensory Neurons In Vitro Is Mediated by Nectin-1/HveC

Sarah M. Richart,1 Scott A. Simpson,2 Claude Krummenacher,3,4 J. Charles Whitbeck,3,4 Lewis I. Pizer,2,5* Gary H. Cohen,3,4 Roselyn J. Eisenberg,4,6 and Christine L. Wilcox1

Department of Microbiology, Colorado State University, Fort Collins,1 Department of Microbiology,2 Molecular Biology Program, University of Colorado Health Sciences Center, Denver, Colorado,5 Department of Microbiology,3 Center for Oral Health Research,4 School of Dental Medicine, and Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania6

Received 31 October 2002/ Accepted 20 November 2002

Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.

* Corresponding author. Mailing address: University of Colorado Health Sciences Center, Department of Microbiology, B175, Denver, CO 80262. Phone: (303) 315-7320. Fax: (303) 315-6785. E-mail: lew.pizer{at}uchsc.edu.

Journal of Virology, March 2003, p. 3307-3311, Vol. 77, No. 5
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.5.3307-3311.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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