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Journal of Virology, February 2003, p. 2789-2798, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2789-2798.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Bovine Enteric Caliciviruses: a Distinct Third Genogroup of Noroviruses (Norwalk-Like Viruses) Unlikely To Be of Risk to Humans

S. L. Oliver,1 A. M. Dastjerdi,1 S. Wong,1,{dagger} L. El-Attar,1 C. Gallimore,2 D. W. G. Brown,2 J. Green,2 and J. C. Bridger1*

Department of Pathology & Infectious Diseases, Royal Veterinary College, London NW1 OTU,1 Enteric and Respiratory Virus Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom2

Received 16 August 2002/ Accepted 12 November 2002

Bovine enteric caliciviruses (BoCVs) have been classified in the Norovirus (Norwalk-like virus) genus of the Caliciviridae, raising questions about zoonotic transmission and an animal reservoir for the human Norwalk-like viruses (NLVs), an important cause of nonbacterial gastroenteritis in humans. We examined the genetic relationship of human NLVs to BoCVs that were identified by using reverse transcription-PCR with primer pairs originally designed to detect human NLVs. Polymerase, capsid, and open reading frame 3 (ORF3) gene sequence analyses of BoCVs that were identified from 1976 to 2000 from throughout the United Kingdom showed that BoCVs formed a distinct third genogroup of closely related viruses distinct from the human genogroup I and II NLVs. Evidence was not obtained to support the concept that BoCVs are circulating in humans and pose a threat to human health.

* Corresponding author. Mailing address: Department of Pathology & Infectious Diseases, Royal Veterinary College, Royal College St., London NW1 OTU, United Kingdom. Phone: 44 207 468 5221. Fax: 44 207 468 5306. E-mail: jbridger{at}rvc.ac.uk.

{dagger} Present address: Merial Asia Pte. Ltd., Singapore 118238, Republic of Singapore.

Journal of Virology, February 2003, p. 2789-2798, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2789-2798.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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