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Human Immunodeficiency Virus Type 1 Attachment, Coreceptor, and Fusion Inhibitors Are Active against both Direct and trans Infection of Primary Cells

Progenics Pharmaceuticals, Inc., Tarrytown, New York 10591,¹ Department of Microbiology and Immunology,⁴ Department of Pediatrics, Weill Medical College of Cornell University,⁵ Center for Biomedical Research, Population Council, New York, New York 10021,² Jefferiss Research Trust Laboratories, Wright-Fleming Institute, Imperial College, London W2 1PG, United Kingdom³

Received 21 August 2002/ Accepted 18 November 2002

Inhibitors of human immunodeficiency virus type 1 attachment (CD4-immunoglobulin G subclass 2), CCR5 usage (PRO 140), and fusion (T-20) were tested on diverse primary cell types that represent the major targets both for infection in vivo and for the inhibition of trans infection of target cells by virus bound to dendritic cells. Although minor cell-type-dependent differences in potency were observed, each inhibitor was active on each cell type and trans infection was similarly vulnerable to inhibition at each stage of the fusion cascade.

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