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Journal of Virology, February 2003, p. 2757-2761, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2757-2761.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Identification of a TAP-Independent, Immunoproteasome-Dependent CD8+ T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2

Georg Lautscham,1,{dagger} Tracey Haigh,1 Sabine Mayrhofer,1,{ddagger} Graham Taylor,1 Debbie Croom-Carter,1 Alison Leese,1 Stephan Gadola,2,3 Vincenzo Cerundolo,2 Alan Rickinson,1 and Neil Blake1,3*

Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham,1 Institute of Molecular Medicine, John Radcliffe Hospital, Oxford,2 Department of Medical Microbiology, University of Liverpool, Liverpool, United Kingdom3

Received 21 August 2002/ Accepted 13 November 2002

We have identified an HLA-A2-restricted CD8+ T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.

* Corresponding author. Mailing address: Department of Medical Microbiology, University of Liverpool, 8th Floor, Duncan Building, Daulby St., Liverpool L69 3GA, United Kingdom. Phone: 44-151-706 4386. Fax: 44-151-706 5805. E-mail: nwblake{at}liv.ac.uk.

{dagger} Present address: Max Delbrueck Center for Molecular Medicine, Berlin, Germany.

{ddagger} Present address: Universitaet Köln, Hodgkinlabor, LFI, Cologne, Germany.

§ Present address: Department of Rheumatology and Clinical Immunology, University Hospital, Bern, Switzerland.

Journal of Virology, February 2003, p. 2757-2761, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2757-2761.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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