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Journal of Virology, February 2003, p. 2753-2756, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2753-2756.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Targeted Retroviral Infection of Tumor Cells by Receptor Cooperation

Francisco Martin,^1, Simon Chowdhury,¹ Stuart J. Neil,¹ Kerry A. Chester,² Francois-Loic Cosset,³ and Mary K. Collins^1*

Department of Immunology and Molecular Pathology, Windeyer Institute,¹ CRC Targeting and Imaging Group, Department of Oncology, Royal Free and University College Medical School, London, United Kingdom,² Laboratoire Vectorologie Retrovirale et Therapie Genique, Unite de Virologie, Humaine, U412 INSERM, IFR 74 and ENS de Lyon, France³

Received 23 July 2002/ Accepted 14 November 2002

Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.

Present address: Unidad Mixta de Investigaciones Médicas, Hospital Clínico San Cecilio, Granada, Spain.

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