This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mori, Y.
Right arrow Articles by Yamanishi, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mori, Y.
Right arrow Articles by Yamanishi, K.

 Previous Article  |  Next Article 

Journal of Virology, February 2003, p. 2452-2458, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2452-2458.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Human Herpesvirus 6 U100 Gene Product Is the Third Component of the gH-gL Glycoprotein Complex on the Viral Envelope

Yasuko Mori,* Pilailuk Akkapaiboon, Xuwei Yang, and Koichi Yamanishi

Department of Microbiology, Osaka University Medical School, Osaka 565-0871, Japan

Received 10 September 2002/ Accepted 13 November 2002

The human herpesvirus 6 (HHV-6) variant A U100 gene encodes the third component of the glycoprotein H (gH)-glycoprotein L (gL)-containing complex. Glycosidase digestion analysis showed that the U100 gene products are glycoproteins consisting of an 80-kDa protein with complex N-linked oligosaccharides and a 74-kDa protein with immature, high-mannose N-linked oligosaccharides. Based on these characteristics, we designated the U100 gene products glycoprotein Q (gQ). Only the 80-kDa form of gQ was coimmunoprecipitated with an anti-gH antibody, suggesting that the 80-kDa protein associates with the gH-gL complex in HHV-6-infected cells. Furthermore, the complex was detected in purified virions, suggesting that it may play an important role in viral entry.

* Corresponding author. Mailing address: Department of Microbiology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-3321. Fax: 81-6-6879-3329. E-mail: ymori{at}micro.med.osaka-u.ac.jp.

Journal of Virology, February 2003, p. 2452-2458, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2452-2458.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pedersen, S. M., Oster, B., Bundgaard, B., Hollsberg, P. (2006). Induction of Cell-Cell Fusion from Without by Human Herpesvirus 6B. J. Virol. 80: 9916-9920 [Abstract] [Full Text]  
  • Adler, B., Scrivano, L., Ruzcics, Z., Rupp, B., Sinzger, C., Koszinowski, U. (2006). Role of human cytomegalovirus UL131A in cell type-specific virus entry and release. J. Gen. Virol. 87: 2451-2460 [Abstract] [Full Text]  
  • Sadaoka, T., Yamanishi, K., Mori, Y. (2006). Human herpesvirus 7 U47 gene products are glycoproteins expressed in virions and associate with glycoprotein H.. J. Gen. Virol. 87: 501-508 [Abstract] [Full Text]  
  • Huang, H., Li, Y., Sadaoka, T., Tang, H., Yamamoto, T., Yamanishi, K., Mori, Y. (2006). Human herpesvirus 6 envelope cholesterol is required for virus entry. J. Gen. Virol. 87: 277-285 [Abstract] [Full Text]  
  • Takemoto, M., Koike, M., Mori, Y., Yonemoto, S., Sasamoto, Y., Kondo, K., Uchiyama, Y., Yamanishi, K. (2005). Human Herpesvirus 6 Open Reading Frame U14 Protein and Cellular p53 Interact with Each Other and Are Contained in the Virion. J. Virol. 79: 13037-13046 [Abstract] [Full Text]  
  • Ressing, M. E., van Leeuwen, D., Verreck, F. A. W., Keating, S., Gomez, R., Franken, K. L. M. C., Ottenhoff, T. H. M., Spriggs, M., Schumacher, T. N., Hutt-Fletcher, L. M., Rowe, M., Wiertz, E. J. H. J. (2005). Epstein-Barr Virus gp42 Is Posttranslationally Modified To Produce Soluble gp42 That Mediates HLA Class II Immune Evasion. J. Virol. 79: 841-852 [Abstract] [Full Text]  
  • Lopes, F. B., Colaco, S., May, J. S., Stevenson, P. G. (2004). Characterization of Murine Gammaherpesvirus 68 Glycoprotein B. J. Virol. 78: 13370-13375 [Abstract] [Full Text]  
  • Akkapaiboon, P., Mori, Y., Sadaoka, T., Yonemoto, S., Yamanishi, K. (2004). Intracellular Processing of Human Herpesvirus 6 Glycoproteins Q1 and Q2 into Tetrameric Complexes Expressed on the Viral Envelope. J. Virol. 78: 7969-7983 [Abstract] [Full Text]  
  • Mori, Y., Akkapaiboon, P., Yonemoto, S., Koike, M., Takemoto, M., Sadaoka, T., Sasamoto, Y., Konishi, S., Uchiyama, Y., Yamanishi, K. (2004). Discovery of a Second Form of Tripartite Complex Containing gH-gL of Human Herpesvirus 6 and Observations on CD46. J. Virol. 78: 4609-4616 [Abstract] [Full Text]  
  • Santoro, F., Greenstone, H. L., Insinga, A., Liszewski, M. K., Atkinson, J. P., Lusso, P., Berger, E. A. (2003). Interaction of Glycoprotein H of Human Herpesvirus 6 with the Cellular Receptor CD46. J. Biol. Chem. 278: 25964-25969 [Abstract] [Full Text]  
  • Mori, Y., Yang, X., Akkapaiboon, P., Okuno, T., Yamanishi, K. (2003). Human Herpesvirus 6 Variant A Glycoprotein H-Glycoprotein L-Glycoprotein Q Complex Associates with Human CD46. J. Virol. 77: 4992-4999 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»