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Journal of Virology, February 2003, p. 2418-2425, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2418-2425.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

TT Virus in the Nasal Secretions of Children with Acute Respiratory Diseases: Relations to Viremia and Disease Severity

Fabrizio Maggi,1 Massimo Pifferi,2 Claudia Fornai,1 Elisabetta Andreoli,1 Elena Tempestini,1 Marialinda Vatteroni,1 Silvano Presciuttini,1 Santino Marchi,3 Angelo Pietrobelli,4 Attilio Boner,4 Mauro Pistello,1 and Mauro Bendinelli1*

Virology Section and Retrovirus Center, Department of Experimental Pathology,1 Department of Pediatrics,2 Gastroenterology Unit, University of Pisa, Pisa,3 Department of Pediatrics, University of Verona, Verona, Italy4

Received 15 April 2002/ Accepted 12 November 2002

The natural history and pathogenic potential of the recently identified TT virus (TTV) are currently a matter of intensive investigation. In an attempt to shed some light on these issues, nasal and blood specimens of 1- to 24-month-old children hospitalized with a clinical diagnosis of acute respiratory disease (ARD) were examined for the presence, load, and genetic characteristics of TTV. The results have indicated that at least in young children, the respiratory tract not only represents a route by which abundant TTV can be shed into the environment but also may be a site of primary infection and continual replication. Although we found no compelling evidence that TTV was the direct cause of ARD in some of the children studied, the average loads of TTV were considerably higher in patients with bronchopneumonia (BP) than in those with milder ARD, raising interesting questions about the pathophysiological significance of TTV at this site. Furthermore, group 4 TTV was detected almost exclusively in children with BP.

* Corresponding author. Mailing address: Virology Section and Retrovirus Center, Department of Experimental Pathology, University of Pisa, Via San Zeno 37, I-56127 Pisa, Italy. Phone: 39 050 221.3641. Fax: 39 050 221.3639. E-mail: bendinelli{at}biomed.unipi.it.

Journal of Virology, February 2003, p. 2418-2425, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2418-2425.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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