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Journal of Virology, February 2003, p. 2258-2264, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2258-2264.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Recognition of a Novel Stage of Betaherpesvirus Latency in Human Herpesvirus 6

Kazuhiro Kondo,1* Junji Sashihara,2 Kazuya Shimada,1 Masaya Takemoto,1 Kiyoko Amo,2 Hiromi Miyagawa,2 and Koichi Yamanishi1

Department of Microbiology,1 Department of Pediatrics, Osaka University Medical School, Suita City, Osaka 565-0871, Japan2

Received 28 June 2002/ Accepted 24 October 2002

Latency-associated transcripts of human herpesvirus 6 (H6LTs) (K. Kondo et al. J. Virol. 76:4145-4151, 2002) were maximally expressed at a fairly stable intermediate stage between latency and reactivation both in vivo and in vitro. H6LTs functioned as sources of immediate-early protein 1 at this stage, which up-regulated the viral reactivation.

* Corresponding author. Mailing address: Department of Microbiology, Osaka University Medical School C1, 2-2 Yamada-Oka, Suita City, Osaka 565-0871, Japan. Phone: 816-6879-3323. Fax: 816-6879-3329. E-mail: kkondo{at}micro.med.osaka-u.ac.jp.

Journal of Virology, February 2003, p. 2258-2264, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2258-2264.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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