This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Howard, L. M.
Right arrow Articles by Miller, S. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Howard, L. M.
Right arrow Articles by Miller, S. D.

 Previous Article  |  Next Article 

Journal of Virology, February 2003, p. 2247-2250, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2247-2250.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

CD154 Blockade Results in Transient Reduction in Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease

Laurence M. Howard,1,2 Katherine L. Neville,1,2 Lia M. Haynes,1,2 Mauro C. Dal Canto,2,3 and Stephen D. Miller1,2*

Departments of Microbiology-Immunology,1 and Pathology,3 and Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 606112

Received 8 July 2002/ Accepted 7 November 2002

Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.


* Corresponding author. Mailing address: Department of Microbiology-Immunology, Northwestern University Medical School, 303 East Chicago Ave., Chicago, IL 60611. Phone: (312) 503-7674. Fax: (312) 503-1339. E-mail: s-d-miller{at}nwu.edu.


Journal of Virology, February 2003, p. 2247-2250, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2247-2250.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Chen, K., Iribarren, P., Huang, J., Zhang, L., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M., Wang, J. M. (2007). Induction of the Formyl Peptide Receptor 2 in Microglia by IFN-{gamma} and Synergy with CD40 Ligand. J. Immunol. 178: 1759-1766 [Abstract] [Full Text]  
  • Trottier, M., Schlitt, B. P., Kung, A. Y., Lipton, H. L. (2004). Transition from Acute to Persistent Theiler's Virus Infection Requires Active Viral Replication That Drives Proinflammatory Cytokine Expression and Chronic Demyelinating Disease. J. Virol. 78: 12480-12488 [Abstract] [Full Text]