Previous Article | Next Article 
Journal of Virology, February 2003, p. 2247-2250, Vol. 77, No. 3
0022-538X/03/$08.00+0 DOI: 10.1128/JVI.77.3.2247-2250.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
CD154 Blockade Results in Transient Reduction in Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease
Laurence M. Howard,1,2 Katherine L. Neville,1,2 Lia M. Haynes,1,2 Mauro C. Dal Canto,2,3 and Stephen D. Miller1,2*
Departments of Microbiology-Immunology,1
and Pathology,3
and Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 606112
Received 8 July 2002/
Accepted 7 November 2002
Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.
* Corresponding author. Mailing address: Department of Microbiology-Immunology, Northwestern University Medical School, 303 East Chicago Ave., Chicago, IL 60611. Phone: (312) 503-7674. Fax: (312) 503-1339. E-mail: s-d-miller{at}nwu.edu.
Journal of Virology, February 2003, p. 2247-2250, Vol. 77, No. 3
0022-538X/03/$08.00+0 DOI: 10.1128/JVI.77.3.2247-2250.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
This article has been cited by other articles:
-
Chen, K., Iribarren, P., Huang, J., Zhang, L., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M., Wang, J. M.
(2007). Induction of the Formyl Peptide Receptor 2 in Microglia by IFN-{gamma} and Synergy with CD40 Ligand. J. Immunol.
178: 1759-1766
[Abstract]
[Full Text]
-
Trottier, M., Schlitt, B. P., Kung, A. Y., Lipton, H. L.
(2004). Transition from Acute to Persistent Theiler's Virus Infection Requires Active Viral Replication That Drives Proinflammatory Cytokine Expression and Chronic Demyelinating Disease. J. Virol.
78: 12480-12488
[Abstract]
[Full Text]
Copyright © 2003 by the American Society for Microbiology. All rights reserved.