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Journal of Virology, February 2003, p. 2247-2250, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2247-2250.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

CD154 Blockade Results in Transient Reduction in Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease

Laurence M. Howard,1,2 Katherine L. Neville,1,2 Lia M. Haynes,1,2 Mauro C. Dal Canto,2,3 and Stephen D. Miller1,2*

Departments of Microbiology-Immunology,1 and Pathology,3 and Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 606112

Received 8 July 2002/ Accepted 7 November 2002

Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.

* Corresponding author. Mailing address: Department of Microbiology-Immunology, Northwestern University Medical School, 303 East Chicago Ave., Chicago, IL 60611. Phone: (312) 503-7674. Fax: (312) 503-1339. E-mail: s-d-miller{at}nwu.edu.

Journal of Virology, February 2003, p. 2247-2250, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2247-2250.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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