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Journal of Virology, February 2003, p. 2227-2232, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2227-2232.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vivo Induction of Apoptosis Correlating with Reduced Infectivity during Baculovirus Infection{dagger}

Thomas E. Clarke and Rollie J. Clem*

Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506

Received 5 August 2002/ Accepted 24 October 2002

Spodoptera frugiperda caterpillars were infected with a mutant of Autographa californica M nucleopolyhedrovirus lacking the antiapoptotic p35 gene. Viral infectivity, replication, and spread were substantially reduced compared to that of a control revertant virus. Terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling confirmed that apoptosis occurred in mutant-infected caterpillars, thus directly correlating reduced infectivity and in vivo induction of apoptosis.

* Corresponding author. Mailing address: Division of Biology, 232 Ackert Hall, Kansas State University, Manhattan, KS 66506. Phone: (785) 532-3172. Fax: (785) 532-6653. E-mail: rclem{at}ksu.edu.

{dagger} Contribution number 02-352-J from the Kansas Agricultural Experiment Station.

Journal of Virology, February 2003, p. 2227-2232, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2227-2232.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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