This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schmitz, J. E.
Right arrow Articles by Reimann, K. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schmitz, J. E.
Right arrow Articles by Reimann, K. A.

 Previous Article  |  Next Article 

Journal of Virology, February 2003, p. 2165-2173, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2165-2173.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Effect of Humoral Immune Responses on Controlling Viremia during Primary Infection of Rhesus Monkeys with Simian Immunodeficiency Virus

Jörn E. Schmitz,1 Marcelo J. Kuroda,1 Sampa Santra,1 Meredith A. Simon,2 Michelle A. Lifton,1 Wenyu Lin,1 Rajinder Khunkhun,1 Michael Piatak,3 Jeffrey D. Lifson,3 Gudrun Grosschupff,4 Rebecca S. Gelman,5 Paul Racz,4 Klara Tenner-Racz,4 Keith A. Mansfield,2 Norman L. Letvin,1 David C. Montefiori,6 and Keith A. Reimann1*

Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School,1 Biostatistics Department, Harvard School of Public Health, Boston, Massachusetts 02215,5 Division of Comparative Pathology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772,2 Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 20892,3 Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany,4 Department of Surgery, Duke University Medical Center, Durham, North Carolina 277106

Received 27 August 2002/ Accepted 8 November 2002

Cellular immune responses mediated by CD8+ lymphocytes exert efficient control of virus replication during primary simian immunodeficiency virus (SIV) infection. However, the role that antibodies may play in the early control of virus replication remains unclear. To evaluate how antibody responses may affect virus replication during primary SIVmac infection, we depleted rhesus monkeys of B cells with anti-CD20 antibody. In normal rhesus monkeys immunized with tetanus toxoid, anti-CD20 treatment and resulting depletion of B cells inhibited the generation of antitetanus antibodies, while tetanus-specific T-cell responses were preserved. During the first 4 weeks after inoculation with SIVmac251, development of SIV-specific neutralizing antibody was delayed, and titers were significantly lower in B-cell-depleted monkeys than control-antibody-treated monkeys. Despite the lower neutralizing antibody titers, the levels of plasma SIV RNA and the linear slope of the decline seen in B-cell-depleted monkeys did not differ from that observed in monkeys treated with control antibody. However, beginning at day 28 after SIV infection, the B-cell-depleted monkeys showed a significant inverse correlation between neutralizing antibody titers and plasma virus level. These results suggest that the rapid decline of peak viremia that typically occurs during the first 3 weeks of infection was not significantly affected by SIV-specific antibodies. However, the inverse correlation between neutralizing antibodies and plasma virus level during the postacute phases of infection suggests that humoral immune responses may contribute to the control of SIV replication.

* Corresponding author. Mailing address: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, RE-113, 330 Brookline Ave., Boston, MA 02215. Phone: (617) 667-4583. Fax: (617) 667-8210. E-mail: kreimann{at}caregroup.harvard.edu.

Journal of Virology, February 2003, p. 2165-2173, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2165-2173.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gaufin, T., Gautam, R., Kasheta, M., Ribeiro, R., Ribka, E., Barnes, M., Pattison, M., Tatum, C., MacFarland, J., Montefiori, D., Kaur, A., Pandrea, I., Apetrei, C. (2009). Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain. Blood 113: 4250-4261 [Abstract] [Full Text]  
  • Choi, E. I., Reimann, K. A., Letvin, N. L. (2008). In Vivo Natural Killer Cell Depletion during Primary Simian Immunodeficiency Virus Infection in Rhesus Monkeys. J. Virol. 82: 6758-6761 [Abstract] [Full Text]  
  • Veazey, R. S., Acierno, P. M., McEvers, K. J., Baumeister, S. H. C., Foster, G. J., Rett, M. D., Newberg, M. H., Kuroda, M. J., Williams, K., Kim, E.-Y., Wolinsky, S. M., Rieber, E. P., Piatak, M. Jr., Lifson, J. D., Montefiori, D. C., Brown, C. R., Hirsch, V. M., Schmitz, J. E. (2008). Increased Loss of CCR5+ CD45RA- CD4+ T Cells in CD8+ Lymphocyte-Depleted Simian Immunodeficiency Virus-Infected Rhesus Monkeys. J. Virol. 82: 5618-5630 [Abstract] [Full Text]  
  • Acosta, D. M., Arnaiz, M. R., Esteva, M. I., Barboza, M., Stivale, D., Orlando, U. D., Torres, S., Laucella, S. A., Couto, A. S., Duschak, V. G. (2008). Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice. Int Immunol 20: 461-470 [Abstract] [Full Text]  
  • Miller, C. J., Genesca, M., Abel, K., Montefiori, D., Forthal, D., Bost, K., Li, J., Favre, D., McCune, J. M. (2007). Antiviral Antibodies Are Necessary for Control of Simian Immunodeficiency Virus Replication. J. Virol. 81: 5024-5035 [Abstract] [Full Text]  
  • Edwards, C. T. T., Holmes, E. C., Pybus, O. G., Wilson, D. J., Viscidi, R. P., Abrams, E. J., Phillips, R. E., Drummond, A. J. (2006). Evolution of the Human Immunodeficiency Virus Envelope Gene Is Dominated by Purifying Selection. Genetics 174: 1441-1453 [Abstract] [Full Text]  
  • Margolin, D. H., Saunders, E. H., Bronfin, B., de Rosa, N., Axthelm, M. K., Goloubeva, O. G., Eapen, S., Gelman, R. S., Letvin, N. L. (2006). Germinal Center Function in the Spleen during Simian HIV Infection in Rhesus Monkeys. J. Immunol. 177: 1108-1119 [Abstract] [Full Text]  
  • Lauren, A., Thorstensson, R., Fenyo, E. M. (2006). Comparative studies on mucosal and intravenous transmission of simian immunodeficiency virus (SIVsm): the kinetics of evolution to neutralization resistance are related to progression rate of disease.. J. Gen. Virol. 87: 595-606 [Abstract] [Full Text]  
  • Hel, Z., Tsai, W.-P., Tryniszewska, E., Nacsa, J., Markham, P. D., Lewis, M. G., Pavlakis, G. N., Felber, B. K., Tartaglia, J., Franchini, G. (2006). Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes. J. Immunol. 176: 85-96 [Abstract] [Full Text]  
  • Metzner, K. J., Moretto, W. J., Donahoe, S. M., Jin, X., Gettie, A., Montefiori, D. C., Marx, P. A., Binley, J. M., Nixon, D. F., Connor, R. I. (2005). Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus. J. Gen. Virol. 86: 3375-3384 [Abstract] [Full Text]  
  • Mao, H., Lafont, B. A. P., Igarashi, T., Nishimura, Y., Brown, C., Hirsch, V., Buckler-White, A., Sadjadpour, R., Martin, M. A. (2005). CD8+ and CD20+ Lymphocytes Cooperate To Control Acute Simian Immunodeficiency Virus/Human Immunodeficiency Virus Chimeric Virus Infections in Rhesus Monkeys: Modulation by Major Histocompatibility Complex Genotype. J. Virol. 79: 14887-14898 [Abstract] [Full Text]  
  • Stebbings, R., Berry, N., Waldmann, H., Bird, P., Hale, G., Stott, J., North, D., Hull, R., Hall, J., Lines, J., Brown, S., D'Arcy, N., Davis, L., Elsley, W., Edwards, C., Ferguson, D., Allen, J., Almond, N. (2005). CD8+ Lymphocytes Do Not Mediate Protection against Acute Superinfection 20 Days after Vaccination with a Live Attenuated Simian Immunodeficiency Virus. J. Virol. 79: 12264-12272 [Abstract] [Full Text]  
  • Schmitz, J. E., Johnson, R. P., McClure, H. M., Manson, K. H., Wyand, M. S., Kuroda, M. J., Lifton, M. A., Khunkhun, R. S., McEvers, K. J., Gillis, J., Piatak, M., Lifson, J. D., Grosschupff, G., Racz, P., Tenner-Racz, K., Rieber, E. P., Kuus-Reichel, K., Gelman, R. S., Letvin, N. L., Montefiori, D. C., Ruprecht, R. M., Desrosiers, R. C., Reimann, K. A. (2005). Effect of CD8+ Lymphocyte Depletion on Virus Containment after Simian Immunodeficiency Virus SIVmac251 Challenge of Live Attenuated SIVmac239{Delta}3-Vaccinated Rhesus Macaques. J. Virol. 79: 8131-8141 [Abstract] [Full Text]  
  • Van Rompay, K. K. A., Singh, R. P., Pahar, B., Sodora, D. L., Wingfield, C., Lawson, J. R., Marthas, M. L., Bischofberger, N. (2004). CD8+-Cell-Mediated Suppression of Virulent Simian Immunodeficiency Virus during Tenofovir Treatment. J. Virol. 78: 5324-5337 [Abstract] [Full Text]  
  • Rybarczyk, B. J., Montefiori, D., Johnson, P. R., West, A., Johnston, R. E., Swanstrom, R. (2004). Correlation between env V1/V2 Region Diversification and Neutralizing Antibodies during Primary Infection by Simian Immunodeficiency Virus sm in Rhesus Macaques. J. Virol. 78: 3561-3571 [Abstract] [Full Text]  
  • Draenert, R., Verrill, C. L., Tang, Y., Allen, T. M., Wurcel, A. G., Boczanowski, M., Lechner, A., Kim, A. Y., Suscovich, T., Brown, N. V., Addo, M. M., Walker, B. D. (2004). Persistent Recognition of Autologous Virus by High-Avidity CD8 T Cells in Chronic, Progressive Human Immunodeficiency Virus Type 1 Infection. J. Virol. 78: 630-641 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»