This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, T. C.
Right arrow Articles by Bramson, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, T. C.
Right arrow Articles by Bramson, J.

 Previous Article  |  Next Article 

Journal of Virology, December 2003, p. 13407-13411, Vol. 77, No. 24
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.24.13407-13411.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Detailed Analysis of the CD8+ T-Cell Response following Adenovirus Vaccination

Teng Chih Yang, Kelley Dayball, Yong Hong Wan, and Jonathan Bramson*

Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada

Received 9 May 2003/ Accepted 28 August 2003

We examined CD8+ T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8+ T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8+ T-cell response.

* Corresponding author. Mailing address: Department of Pathology and Molecular Medicine, McMaster University, Room HSC-4H21B, 1200 Main St. West, Hamilton, Ontario L8N 3Z5, Canada. Phone: (905) 525-9140. Fax: (905) 522 6750. E-mail: bramsonj{at}mcmaster.ca.

Journal of Virology, December 2003, p. 13407-13411, Vol. 77, No. 24
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.24.13407-13411.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Finn, J. D., Bassett, J., Millar, J. B., Grinshtein, N., Yang, T. C., Parsons, R., Evelegh, C., Wan, Y., Parks, R. J., Bramson, J. L. (2009). Persistence of Transgene Expression Influences CD8+ T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus. J. Virol. 83: 12027-12036 [Abstract] [Full Text]  
  • Velazquez, V. M., Bowen, D. G., Walker, C. M. (2009). Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy. Blood 113: 538-545 [Abstract] [Full Text]  
  • Divangahi, M., Yang, T., Kugathasan, K., McCormick, S., Takenaka, S., Gaschler, G., Ashkar, A., Stampfli, M., Gauldie, J., Bramson, J., Takai, T., Brown, E., Yokoyama, W. M., Aoki, N., Xing, Z. (2007). Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection. J. Immunol. 179: 4015-4026 [Abstract] [Full Text]  
  • Roghanian, A., Williams, S. E., Sheldrake, T. A., Brown, T. I., Oberheim, K., Xing, Z., Howie, S. E. M., Sallenave, J.-M. (2006). The Antimicrobial/Elastase Inhibitor Elafin Regulates Lung Dendritic Cells and Adaptive Immunity. Am. J. Respir. Cell Mol. Bio. 34: 634-642 [Abstract] [Full Text]  
  • Yang, T.-C., Millar, J., Groves, T., Grinshtein, N., Parsons, R., Takenaka, S., Wan, Y., Bramson, J. L. (2006). The CD8+ T Cell Population Elicited by Recombinant Adenovirus Displays a Novel Partially Exhausted Phenotype Associated with Prolonged Antigen Presentation That Nonetheless Provides Long-Term Immunity. J. Immunol. 176: 200-210 [Abstract] [Full Text]  
  • Yarovinsky, T. O., Mohning, M. P., Bradford, M. A., Monick, M. M., Hunninghake, G. W. (2005). Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection. Infect. Immun. 73: 3375-3384 [Abstract] [Full Text]  
  • Krebs, P., Scandella, E., Odermatt, B., Ludewig, B. (2005). Rapid Functional Exhaustion and Deletion of CTL following Immunization with Recombinant Adenovirus. J. Immunol. 174: 4559-4566 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»