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Characterization of Murine Leukemia Virus Restriction in Mammals

Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF,¹ Department of Biology, University College London, London WC1E 6BT, United Kingdom,² Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032³

Received 9 July 2003/ Accepted 5 September 2003

Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.

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