This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Korotkova, E. A.
Right arrow Articles by Agol, V. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Korotkova, E. A.
Right arrow Articles by Agol, V. I.

 Previous Article  |  Next Article 

Journal of Virology, December 2003, p. 12460-12465, Vol. 77, No. 23
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.23.12460-12465.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Retrospective Analysis of a Local Cessation of Vaccination against Poliomyelitis: a Possible Scenario for the Future

Ekaterina A. Korotkova,1 Renee Park,2 Elena A. Cherkasova,1,3 Galina Y. Lipskaya,1,4 Konstantin M. Chumakov,3 Esfir V. Feldman,5 Olen M. Kew,2 and Vadim I. Agol1,6*

A. N. Belozersky Institute of Physical-Chemical Biology, Moscow State University, Moscow 119899,1 M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow Region 142782, Russia,6 Research Institute for Epidemiology and Microbiology, Minsk 220050, Belarus,5 National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,2 Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852,3 European Regional Office of the World Health Organization, Copenhagen 2100, Denmark4

Received 20 June 2003/ Accepted 27 August 2003

The global eradication of poliomyelitis will require substantial changes in immunization practices. One of the proposed scenarios includes cessation of vaccination with live oral poliovirus vaccine (OPV) and the creation of an OPV stockpile for emergency response in case of the reintroduction of poliovirus into circulation. We describe here a retrospective analysis of the cessation of OPV usage in a region of the Byelorussian Republic of the former Soviet Union in 1963 to 1966. During this period, a widespread circulation and evolution of independent lineages of vaccine-derived polioviruses took place in the region. Some of these lineages appeared to originate from OPV given to 40 children in the community during this period of essentially no vaccinations. The data demonstrate very high risks associated with both the local cessation of OPV vaccination and the proposed use of OPV to control a possible reemergence of poliovirus in the postvaccination period. The high transmissibility of OPV-derived viruses in nonimmune population, documented here, and the known existence of long-term OPV excretors should be also considered in assessing risks of the synchronized global cessation of OPV usage.

* Corresponding author. Mailing address: Institute of Poliomyelitis, Kievskoye Shosse 27 km., Moscow Region 142782, Russia. Phone: 7(095)439-9026. Fax: 7(095)439-9321. E-mail: agol{at}belozersky.msu.ru.

Journal of Virology, December 2003, p. 12460-12465, Vol. 77, No. 23
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.23.12460-12465.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yakovenko, M. L., Korotkova, E. A., Ivanova, O. E., Eremeeva, T. P., Samoilovich, E., Uhova, I., Gavrilin, G. V., Agol, V. I. (2009). Evolution of the Sabin Vaccine into Pathogenic Derivatives without Appreciable Changes in Antigenic Properties: Need for Improvement of Current Poliovirus Surveillance. J. Virol. 83: 3402-3406 [Abstract] [Full Text]  
  • Odoom, J. K., Yunus, Z., Dunn, G., Minor, P. D., Martin, J. (2008). Changes in Population Dynamics during Long-Term Evolution of Sabin Type 1 Poliovirus in an Immunodeficient Patient. J. Virol. 82: 9179-9190 [Abstract] [Full Text]  
  • Zurbriggen, S., Tobler, K., Abril, C., Diedrich, S., Ackermann, M., Pallansch, M. A., Metzler, A. (2008). Isolation of Sabin-Like Polioviruses from Wastewater in a Country Using Inactivated Polio Vaccine. Appl. Environ. Microbiol. 74: 5608-5614 [Abstract] [Full Text]  
  • DeJesus, N., Franco, D., Paul, A., Wimmer, E., Cello, J. (2005). Mutation of a Single Conserved Nucleotide between the Cloverleaf and Internal Ribosome Entry Site Attenuates Poliovirus Neurovirulence. J. Virol. 79: 14235-14243 [Abstract] [Full Text]  
  • Laassri, M., Dragunsky, E., Enterline, J., Eremeeva, T., Ivanova, O., Lottenbach, K., Belshe, R., Chumakov, K. (2005). Genomic Analysis of Vaccine-Derived Poliovirus Strains in Stool Specimens by Combination of Full-Length PCR and Oligonucleotide Microarray Hybridization. J. Clin. Microbiol. 43: 2886-2894 [Abstract] [Full Text]  
  • Cherkasova, E. A., Yakovenko, M. L., Rezapkin, G. V., Korotkova, E. A., Ivanova, O. E., Eremeeva, T. P., Krasnoproshina, L. I., Romanenkova, N. I., Rozaeva, N. R., Sirota, L., Agol, V. I., Chumakov, K. M. (2005). Spread of Vaccine-Derived Poliovirus from a Paralytic Case in an Immunodeficient Child: an Insight into the Natural Evolution of Oral Polio Vaccine. J. Virol. 79: 1062-1070 [Abstract] [Full Text]  
  • Shimizu, H., Thorley, B., Paladin, F. J., Brussen, K. A., Stambos, V., Yuen, L., Utama, A., Tano, Y., Arita, M., Yoshida, H., Yoneyama, T., Benegas, A., Roesel, S., Pallansch, M., Kew, O., Miyamura, T. (2004). Circulation of Type 1 Vaccine-Derived Poliovirus in the Philippines in 2001. J. Virol. 78: 13512-13521 [Abstract] [Full Text]  
  • Martin, J., Odoom, K., Tuite, G., Dunn, G., Hopewell, N., Cooper, G., Fitzharris, C., Butler, K., Hall, W. W., Minor, P. D. (2004). Long-Term Excretion of Vaccine-Derived Poliovirus by a Healthy Child. J. Virol. 78: 13839-13847 [Abstract] [Full Text]  
  • Kilpatrick, D. R., Ching, K., Iber, J., Campagnoli, R., Freeman, C. J., Mishrik, N., Liu, H.-M., Pallansch, M. A., Kew, O. M. (2004). Multiplex PCR Method for Identifying Recombinant Vaccine-Related Polioviruses. J. Clin. Microbiol. 42: 4313-4315 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»