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Role of Macrophage Inflammatory Protein-1 in T-Cell-Mediated Immunity to Viral Infection

Andreas N. Madsen, Anneline Nansen, Jan P. Christensen, and Allan R. Thomsen^*

Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark

Received 4 June 2003/ Accepted 28 July 2003

The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1 (MIP-1) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1-deficient mice. Furthermore, MIP-1 is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1 is not mandatory for T-cell-mediated antiviral immunity.

Present address: Statens Serum Institute, Laboratory of Molecular Virology, Copenhagen, Denmark.

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