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 Previous Article

Journal of Virology, November 2003, p. 12378-12384, Vol. 77, No. 22
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.22.12378-12384.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Role of Macrophage Inflammatory Protein-1{alpha} in T-Cell-Mediated Immunity to Viral Infection

Andreas N. Madsen, Anneline Nansen,{dagger} Jan P. Christensen, and Allan R. Thomsen*

Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark

Received 4 June 2003/ Accepted 28 July 2003

The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1{alpha} (MIP-1{alpha}) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1{alpha}-deficient mice. Furthermore, MIP-1{alpha} is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1{alpha} is not mandatory for T-cell-mediated antiviral immunity.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Immunology, The Panum Institute, 3C Blegdamsvej, DK-2200 Copenhagen N, Denmark. Phone: 45-35327871. Fax: 45-35327891. E-mail: a.r.thomsen{at}immi.ku.dk.

{dagger} Present address: Statens Serum Institute, Laboratory of Molecular Virology, Copenhagen, Denmark.

Journal of Virology, November 2003, p. 12378-12384, Vol. 77, No. 22
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.22.12378-12384.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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