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Journal of Virology, November 2003, p. 12067-12073, Vol. 77, No. 22
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.22.12067-12073.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Vaccine-Induced Immunopathology during Bovine Respiratory Syncytial Virus Infection: Exploring the Parameters of Pathogenesis

Adriaan F. G. Antonis,1* Remco S. Schrijver,1 Franz Daus,1 Paul J. G. M. Steverink,1 Norbert Stockhofe,1 Evert J. Hensen,1 Johannes P. M. Langedijk,1 and Robbert G. van der Most2

Institute for Animal Science and Health (ID-Lelystad), NL-8200 AB Lelystad,1 Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands2

Received 6 June 2003/ Accepted 12 August 2003

The bovine and human respiratory syncytial viruses cause severe lower respiratory tract infections. Effective vaccines against the respiratory syncytial viruses have been lacking since vaccine failures in the 1960s and 1970s. In this report, we describe a bovine respiratory syncytial virus (bRSV) challenge model in which both classical bRSV respiratory infection and vaccine-enhanced immune pathology were reproduced. The classical, formalin-inactivated (FI) bRSV vaccine that has been associated with vaccine failure was efficient in inducing high antibody titers and reducing viral loads but also primed calves for a far more serious enhanced respiratory disease after a bRSV challenge, thereby mimicking the enhanced clinical situation in FI human RSV (hRSV)-immunized and hRSV-infected infants in the 1960s. We show that immunization with FI-bRSV mainly primes a Th2-like inflammatory response that is characterized by a significant eosinophilic influx in the bronchial alveolar lung fluid and lung tissues and high levels of immunoglobulin E serum antibodies. The current model may be useful in the evaluation of new bRSV candidate vaccines for potency and safety.

* Corresponding author. Mailing address: ID-Lelystad, P.O. Box 65, NL-8200 AB Lelystad, The Netherlands. Phone: 31 (0) 320 238220. Fax: 31 (0) 320 238225. E-mail: adriaan.antonis{at}wur.nl.

Journal of Virology, November 2003, p. 12067-12073, Vol. 77, No. 22
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.22.12067-12073.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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