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Journal of Virology, November 2003, p. 11733-11744, Vol. 77, No. 21
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.21.11733-11744.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Accumulation of Immature CD11b^Hi Dendritic Cells

Laboratory of Molecular Biology, Clinical Research Institute of Montréal, Montréal, Québec H2W 1R7,¹ Departments of Medicine,² Microbiology and Immunology, Université de Montréal, Montréal, Québec H3C 3J7,³ Division of Experimental Medicine, McGill University, Montréal, Québec H3G 1A4, Canada⁴

Received 11 September 2002/ Accepted 28 July 2003

CD4C/human immunodeficiency virus (HIV) transgenic mice develop an AIDS-like disease. We used this model to study the effects of HIV-1 on dendritic cells (DC). We found a progressive decrease in total DC numbers in the lymph nodes, with a significant accumulation of CD11b^Hi DC. In the thymus, the recovery of transgenic CD8⁺ DC had a tendency to be lower. Spleen DC were augmented in the marginal zone. Transgenic DC showed a decreased capacity to present antigen in vitro, consistent with their reduced major histocompatibility complex class II expression and impaired maturation profile. The accumulation of immature DC may contribute to disease and may reflect an adaptive advantage for the virus by favoring its replication and preventing the generation of fully functional antiviral responses.

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