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Journal of Virology, October 2003, p. 11274-11278, Vol. 77, No. 20
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.20.11274-11278.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Dissemination of Rat Cytomegalovirus through Infected Granulocytes and Monocytes In Vitro and In Vivo

B. W. A. van der Strate,1,2 J. L. Hillebrands,3 S. S. Lycklama à Nijeholt,1 L. Beljaars,1 C. A. Bruggeman,4 M. J. A. van Luyn,2 J. Rozing,3 T. H. The,5 D. K. F. Meijer,1 G. Molema,1,2 and M. C. Harmsen2*

Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration, University Centre for Pharmacy,1 Immunology Section, Department of Cell Biology, Groningen University Institute for Drug Exploration, University of Groningen, 9713 AV Groningen,3 Medical Biology Section, Department of Pathology and Laboratory Medicine, Groningen University Institute for Drug Exploration,2 Clinical Immunology Section, Department of Internal Medicine, University Hospital Groningen, 9713 GZ Groningen,5 Department of Medical Microbiology, University Hospital of Maastricht, 6229 HX Maastricht, The Netherlands4

Received 21 April 2003/ Accepted 18 July 2003

The role of leukocytes in the in vivo dissemination of cytomegalovirus was studied in this experiment. Rat cytomegalovirus (RCMV) could be transferred to rat granulocytes and monocytes by cocultivation with RCMV-infected fibroblasts in vitro. Intravenous injection of purified infected granulocytes or monocytes resulted in a systemic infection in rats, indicating that our model is a powerful tool to gain further insight into CMV dissemination and the development of new antivirals.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, Groningen University Institute for Drug Exploration, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. Phone: 31-50-361 4776. Fax: 31-50-363 3113. E-mail: M.C.Harmsen{at}med.rug.nl.

Journal of Virology, October 2003, p. 11274-11278, Vol. 77, No. 20
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.20.11274-11278.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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