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Journal of Virology, January 2003, p. 1610-1613, Vol. 77, No. 2
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.2.1610-1613.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Baseline Susceptibility of Primary Human Immunodeficiency Virus Type 1 to Entry Inhibitors

Béatrice Labrosse,1 Jean-Louis Labernardière,2 Elisabeth Dam,2 Virginie Trouplin,2 Katharina Skrabal,1 François Clavel,1 and Fabrizio Mammano1*

INSERM U-552, Recherche Antivirale, Hôpital Bichat-Claude Bernard,1 Viralliance SAS, Paris, France2

Received 31 July 2002/ Accepted 16 October 2002

Human immunodeficiency virus type 1 plasma viruses from 29 entry inhibitor-naive patients were characterized for their susceptibilities to T-20, AMD3100, and RANTES. A strikingly wide range of susceptibilities to T-20 was observed that was influenced by coreceptor usage but not by the susceptibilities of the viruses to inhibitors that target the chemokine receptors or by polymorphisms in the gp41 N helix.

* Corresponding author. Mailing address: INSERM U-552, Unité de Recherche Antivirale, Hôpital Bichat-Claude Bernard, 46, rue Henri Huchard, 75018 Paris, France. Phone: 33-1-4025 6368. Fax: 33-1-4025 6370. E-mail: mammano{at}bichat.inserm.fr.

Journal of Virology, January 2003, p. 1610-1613, Vol. 77, No. 2
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.2.1610-1613.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Moore, J. P., Doms, R. W. (2003). The entry of entry inhibitors: A fusion of science and medicine. Proc. Natl. Acad. Sci. USA 100: 10598-10602 [Abstract] [Full Text]  
  • Lin, P.-F., Blair, W., Wang, T., Spicer, T., Guo, Q., Zhou, N., Gong, Y.-F., Wang, H.-G. H., Rose, R., Yamanaka, G., Robinson, B., Li, C.-B., Fridell, R., Deminie, C., Demers, G., Yang, Z., Zadjura, L., Meanwell, N., Colonno, R. (2003). From the Cover: A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding. Proc. Natl. Acad. Sci. USA 100: 11013-11018 [Abstract] [Full Text]  


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