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Journal of Virology, January 2003, p. 1571-1577, Vol. 77, No. 2
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.2.1571-1577.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Development of a Dual Recombinant Vaccine To Protect Small Ruminants against Peste-des-Petits-Ruminants Virus and Capripoxvirus Infections

G. Berhe,1 C. Minet,1 C. Le Goff,1 T. Barrett,2 A. Ngangnou,3 C. Grillet,1 G. Libeau,1 M. Fleming,2 D. N. Black,2 and A. Diallo1*

Cirad, Programme Santé Animale, Campus International de Baillarguet, 34398 Montpellier Cedex 05, France,1 Institute of Animal Health, Pirbright Laboratory, Pirbright, Surrey GU 24 ONF, United Kingdom,2 LANAVET, Garoua, Cameroon3

Received 19 June 2002/ Accepted 17 October 2002

A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain.

* Corresponding author. Present address: Animal Production Unit, FAO/IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories, A-2444 Seibersdorf, Austria. Phone: (43-1) 2600 28355. Fax: (43-1) 2600 28222. E-mail: a.diallo{at}iaea.org.

Journal of Virology, January 2003, p. 1571-1577, Vol. 77, No. 2
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.2.1571-1577.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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