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Journal of Virology, January 2003, p. 1237-1244, Vol. 77, No. 2
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.2.1237-1244.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Altered Pathogenesis of Severe Pneumovirus Infection in Response to Combined Antiviral and Specific Immunomodulatory Agents

Cynthia A. Bonville,1 Andrew J. Easton,2 Helene F. Rosenberg,3 and Joseph B. Domachowske1*

Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York 13210,1 Department of Biological Sciences, University of Warwick, Coventry, United Kingdom,2 Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208923

Received 31 July 2002/ Accepted 11 October 2002

We report here the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. Mice infected with pneumonia virus of mice, a natural mouse pathogen that replicates the signs and symptoms of severe infection with respiratory syncytial virus (RSV), responded to the antiviral agent ribavirin when it was administered in the setting of endogenous (gene deletion) or exogenous (antibody-mediated) blockade of the MIP-1{alpha} proinflammatory signaling cascade. Although neither treatment is effective alone, together they offer a dramatic reduction in symptoms and pathology, the most impressive of which is a significant reduction in morbidity and mortality. The findings presented are consistent with the notion of unique and independent contributions of virus replication and ongoing inflammation to the pathogenesis of severe respiratory virus infection, and they provide the impetus for the study of this treatment regimen in RSV-infected humans.

* Corresponding author. Mailing address: Department of Pediatrics, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210. Phone: (315) 464-7505. Fax: (315) 464-7564. E-mail: domachoj{at}upstate.edu.

Journal of Virology, January 2003, p. 1237-1244, Vol. 77, No. 2
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.2.1237-1244.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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