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Journal of Virology, October 2003, p. 10719-10724, Vol. 77, No. 19
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.19.10719-10724.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Detection of a Gene Cluster That Is Dispensable for Human Herpesvirus 6 Replication and Latency

Kazuhiro Kondo,1,2* Hideo Nozaki,2 Kazuya Shimada,2 and Koichi Yamanishi2

Department of Microbiology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461,1 Department of Microbiology, Osaka University Medical School, Suita-city, Osaka 565-0871, Japan2

Received 4 March 2003/ Accepted 25 June 2003

The U3-U7 gene cluster of human herpesvirus 6 (HHV-6) was replaced with an enhanced green fluorescent protein-puromycin gene cassette containing the cytomegalovirus major immediate-early promoter. Neither viral replication in T cells nor latency and reactivation in macrophages was impaired. During HHV-6 latency, the cytomegalovirus promoter used the transcription start sites employed in cytomegalovirus latency.

* Corresponding author. Mailing address: Department of Microbiology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan. Phone: 81-3-3433-1111. Fax: 81-3-3434-1629. E-mail: kkondo{at}jikei.ac.jp.

Journal of Virology, October 2003, p. 10719-10724, Vol. 77, No. 19
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.19.10719-10724.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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