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Journal of Virology, October 2003, p. 10714-10718, Vol. 77, No. 19
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.19.10714-10718.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Gene That Encodes the Herpes Simplex Virus Type 1 Latency-Associated Transcript Influences the Accumulation of Transcripts (Bcl-xL and Bcl-xS) That Encode Apoptotic Regulatory Proteins

Weiping Peng,1 Gail Henderson,1 Guey-Chuen Perng,2 Anthony B. Nesburn,2 Steven L. Wechsler,2 and Clinton Jones1*

Department of Veterinary and Biomedical Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska 68583-0905,1 Department of Ophthalmology, University of California Irvine College of Medicine, Irvine, California 92697-43752

Received 1 April 2003/ Accepted 14 July 2003

The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells. Bcl-xL encodes an antiapoptotic protein, whereas Bcl-xS encodes a proapoptotic protein. Promoting the accumulation of Bcl-xL in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

* Corresponding author. Mailing address: Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Fair St. at East Campus Loop, Lincoln, NE 68583-0905. Phone: (402) 472-1890. Fax: (402) 472-9690. E-mail: cjones{at}unlnotes.unl.edu.

Journal of Virology, October 2003, p. 10714-10718, Vol. 77, No. 19
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.19.10714-10718.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Meyer, F., Perez, S., Geiser, V., Sintek, M., Inman, M., Jones, C. (2007). A Protein Encoded by the Bovine Herpesvirus 1 Latency-Related Gene Interacts with Specific Cellular Regulatory Proteins, Including CCAAT Enhancer Binding Protein Alpha. J. Virol. 81: 59-67 [Abstract] [Full Text]  
  • Jones, C., Inman, M., Peng, W., Henderson, G., Doster, A., Perng, G.-C., Angeletti, A. K. (2005). The Herpes Simplex Virus Type 1 Locus That Encodes the Latency-Associated Transcript Enhances the Frequency of Encephalitis in Male BALB/c Mice. J. Virol. 79: 14465-14469 [Abstract] [Full Text]  
  • Jin, L., Perng, G.-C., Mott, K. R., Osorio, N., Naito, J., Brick, D. J., Carpenter, D., Jones, C., Wechsler, S. L. (2005). A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse. J. Virol. 79: 12286-12295 [Abstract] [Full Text]  
  • Peng, W., Henderson, G., Inman, M., BenMohamed, L., Perng, G.-C., Wechsler, S. L., Jones, C. (2005). The Locus Encompassing the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Interferes with and Delays Interferon Expression in Productively Infected Neuroblastoma Cells and Trigeminal Ganglia of Acutely Infected Mice. J. Virol. 79: 6162-6171 [Abstract] [Full Text]  


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