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Journal of Virology, October 2003, p. 10714-10718, Vol. 77, No. 19
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.19.10714-10718.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Gene That Encodes the Herpes Simplex Virus Type 1 Latency-Associated Transcript Influences the Accumulation of Transcripts (Bcl-x_L and Bcl-x_S) That Encode Apoptotic Regulatory Proteins

Department of Veterinary and Biomedical Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska 68583-0905,¹ Department of Ophthalmology, University of California Irvine College of Medicine, Irvine, California 92697-4375²

Received 1 April 2003/ Accepted 14 July 2003

The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-x_L transcript versus the Bcl-x_S transcript in Neuro-2A cells. Bcl-x_L encodes an antiapoptotic protein, whereas Bcl-x_S encodes a proapoptotic protein. Promoting the accumulation of Bcl-x_L in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

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