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Journal of Virology, October 2003, p. 10663-10669, Vol. 77, No. 19
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.19.10663-10669.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Cell-Derived Sequences in the N-Terminal Region of the Polyprotein of a Cytopathogenic Pestivirus

A. Müller, G. Rinck, H.-J. Thiel, and N. Tautz*

Institut für Virologie (Fachbereich Veterinärmedizin), Justus-Liebig-Universität Giessen, D-35392 Giessen, Germany

Received 23 May 2003/ Accepted 11 July 2003

Efficient proteolytic release of nonstructural protein 3 (NS3) from the viral polyprotein is considered to be crucial for the cytopathogenicity of pestiviruses. Here we describe a novel cytopathogenic (cp) bovine viral diarrhea virus strain (BVDV CP8) with a complex insertion composed of viral and cell-derived sequences, including two fragments of the cellular J-domain protein Jiv (J-domain protein interacting with viral protein) located in the N-terminal region of the polyprotein. BVDV CP8 expresses a Jiv fusion protein of 513 amino acids in addition to a complete set of viral proteins. This protein has the capacity to induce NS2-3 cleavage in trans. Accordingly, CP8 is a representative of a novel type of cp pestivirus with a cp-specific mutation located outside of the NS2-3 gene.

* Corresponding author. Mailing address: Institut für Virologie (Fachbereich Veterinärmedizin), Justus-Liebig-Universität Giessen, Frankfurter Strasse 107, 35392 Giessen, Germany. Phone: 49-641-99-38375. Fax: 49-641-99-38359. E-mail: Norbert.Tautz{at}vetmed.uni-giessen.de.

Journal of Virology, October 2003, p. 10663-10669, Vol. 77, No. 19
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.19.10663-10669.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Lackner, T., Muller, A., Konig, M., Thiel, H.-J., Tautz, N. (2005). Persistence of Bovine Viral Diarrhea Virus Is Determined by a Cellular Cofactor of a Viral Autoprotease. J. Virol. 79: 9746-9755 [Abstract] [Full Text]  


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