This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ashkar, A. A.
Right arrow Articles by Rosenthal, K. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ashkar, A. A.
Right arrow Articles by Rosenthal, K. L.

 Previous Article  |  Next Article 

Journal of Virology, September 2003, p. 10168-10171, Vol. 77, No. 18
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.18.10168-10171.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interleukin-15 and Natural Killer and NKT Cells Play a Critical Role in Innate Protection against Genital Herpes Simplex Virus Type 2 Infection

Ali A. Ashkar* and Kenneth L. Rosenthal

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

Received 24 March 2003/ Accepted 3 June 2003

Interleukin-15 (IL-15), natural killer (NK) cells, and NK T (NKT) cells, components of the innate immune system, are known to contribute to defense against pathogens, including viruses. Here we report that IL-15-/- (NK- and NKT-/+) mice and RAG-2-/-/{gamma}c-/- (NK- and NKT-) mice that lack all lymphoid cells were very susceptible to vaginal infection with a low dose of herpes simplex virus type 2 (HSV-2). IL-15-/- and RAG-2-/-/{gamma}c-/- mice were 100-fold more susceptible and RAG-2-/-, CD-1-/- (NKT-), and gamma interferon (IFN-{gamma})-/- mice were 10-fold more susceptible to vaginal HSV-2 infection than control C57BL/6 mice. NK and/or NKT cells were the early source of IFN-{gamma} in vaginal secretions following genital HSV-2 infection. This study demonstrates that IL-15 and NK-NKT cells are critical for innate protection against genital HSV-2.

* Corresponding author. Mailing address: Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Rm. 4H30G, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5. Phone: (905) 525-9140, ext. 22311. Fax: (905) 522-6750. E-mail: ashkara{at}mcmaster.ca.

Journal of Virology, September 2003, p. 10168-10171, Vol. 77, No. 18
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.18.10168-10171.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ishikawa, T., Yamada, H., Oyamada, A., Goshima, F., Nishiyama, Y., Yoshikai, Y. (2009). Protective Role of Fas-FasL Signaling in Lethal Infection with Herpes Simplex Virus Type 2 in Mice. J. Virol. 83: 11777-11783 [Abstract] [Full Text]  
  • Kwant-Mitchell, A., Ashkar, A. A., Rosenthal, K. L. (2009). Mucosal Innate and Adaptive Immune Responses against Herpes Simplex Virus Type 2 in a Humanized Mouse Model. J. Virol. 83: 10664-10676 [Abstract] [Full Text]  
  • Thapa, M., Carr, D. J. J. (2009). CXCR3 Deficiency Increases Susceptibility to Genital Herpes Simplex Virus Type 2 Infection: Uncoupling of CD8+ T-Cell Effector Function but Not Migration. J. Virol. 83: 9486-9501 [Abstract] [Full Text]  
  • Lindqvist, M., Persson, J., Thorn, K., Harandi, A. M. (2009). The Mucosal Adjuvant Effect of {alpha}-Galactosylceramide for Induction of Protective Immunity to Sexually Transmitted Viral Infection. J. Immunol. 182: 6435-6443 [Abstract] [Full Text]  
  • Kassim, S. H., Rajasagi, N. K., Ritz, B. W., Pruett, S. B., Gardner, E. M., Chervenak, R., Jennings, S. R. (2009). Dendritic Cells Are Required for Optimal Activation of Natural Killer Functions following Primary Infection with Herpes Simplex Virus Type 1. J. Virol. 83: 3175-3186 [Abstract] [Full Text]  
  • Gill, N., Ashkar, A. A. (2009). Overexpression of Interleukin-15 Compromises CD4-Dependent Adaptive Immune Responses against Herpes Simplex Virus 2. J. Virol. 83: 918-926 [Abstract] [Full Text]  
  • Renukaradhya, G. J., Khan, M. A., Shaji, D., Brutkiewicz, R. R. (2008). Vesicular Stomatitis Virus Matrix Protein Impairs CD1d-Mediated Antigen Presentation through Activation of the p38 MAPK Pathway. J. Virol. 82: 12535-12542 [Abstract] [Full Text]  
  • Sorensen, L. N., Reinert, L. S., Malmgaard, L., Bartholdy, C., Thomsen, A. R., Paludan, S. R. (2008). TLR2 and TLR9 Synergistically Control Herpes Simplex Virus Infection in the Brain. J. Immunol. 181: 8604-8612 [Abstract] [Full Text]  
  • Grubor-Bauk, B., Arthur, J. L., Mayrhofer, G. (2008). Importance of NKT Cells in Resistance to Herpes Simplex Virus, Fate of Virus-Infected Neurons, and Level of Latency in Mice. J. Virol. 82: 11073-11083 [Abstract] [Full Text]  
  • Ahmad, R., El Bassam, S., Cordeiro, P., Menezes, J. (2008). Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1. Blood 112: 2360-2368 [Abstract] [Full Text]  
  • Chiba, A., Dascher, C. C., Besra, G. S., Brenner, M. B. (2008). Rapid NKT Cell Responses Are Self-Terminating during the Course of Microbial Infection. J. Immunol. 181: 2292-2302 [Abstract] [Full Text]  
  • Raftery, M. J., Hitzler, M., Winau, F., Giese, T., Plachter, B., Kaufmann, S. H. E., Schonrich, G. (2008). Inhibition of CD1 Antigen Presentation by Human Cytomegalovirus. J. Virol. 82: 4308-4319 [Abstract] [Full Text]  
  • Thapa, M., Welner, R. S., Pelayo, R., Carr, D. J. J. (2008). CXCL9 and CXCL10 Expression Are Critical for Control of Genital Herpes Simplex Virus Type 2 Infection through Mobilization of HSV-Specific CTL and NK Cells to the Nervous System. J. Immunol. 180: 1098-1106 [Abstract] [Full Text]  
  • Kagimoto, Y., Yamada, H., Ishikawa, T., Maeda, N., Goshima, F., Nishiyama, Y., Furue, M., Yoshikai, Y. (2008). A regulatory role of interleukin 15 in wound healing and mucosal infection in mice. J. Leukoc. Biol. 83: 165-172 [Abstract] [Full Text]  
  • Mizrahi, S., Yefenof, E., Gross, M., Attal, P., Ben Yaakov, A., Goldman-Wohl, D., Maly, B., Stern, N., Katz, G., Gazit, R., Sionov, R. V., Mandelboim, O., Chaushu, S. (2007). A phenotypic and functional characterization of NK cells in adenoids. J. Leukoc. Biol. 82: 1095-1105 [Abstract] [Full Text]  
  • Li, H., Zeng, Z., Fu, X., Zhang, X. (2007). Coadministration of a Herpes Simplex Virus-2 Based Oncolytic Virus and Cyclophosphamide Produces a Synergistic Antitumor Effect and Enhances Tumor-Specific Immune Responses. Cancer Res. 67: 7850-7855 [Abstract] [Full Text]  
  • Thapa, M., Kuziel, W. A., Carr, D. J. J. (2007). Susceptibility of CCR5-Deficient Mice to Genital Herpes Simplex Virus Type 2 Is Linked to NK Cell Mobilization. J. Virol. 81: 3704-3713 [Abstract] [Full Text]  
  • Parker, A. K., Parker, S., Yokoyama, W. M., Corbett, J. A., Buller, R. M. L. (2007). Induction of Natural Killer Cell Responses by Ectromelia Virus Controls Infection. J. Virol. 81: 4070-4079 [Abstract] [Full Text]  
  • Bird, M. D., Chu, C.-F., Johnson, A. J., Milligan, G. N. (2007). Early Resolution of Herpes Simplex Virus Type 2 Infection of the Murine Genital Tract Involves Stimulation of Genital Parenchymal Cells by Gamma Interferon. J. Virol. 81: 423-426 [Abstract] [Full Text]  
  • Raftery, M. J., Winau, F., Kaufmann, S. H. E., Schaible, U. E., Schonrich, G. (2006). CD1 Antigen Presentation by Human Dendritic Cells as a Target for Herpes Simplex Virus Immune Evasion. J. Immunol. 177: 6207-6214 [Abstract] [Full Text]  
  • Gill, N., Deacon, P. M., Lichty, B., Mossman, K. L., Ashkar, A. A. (2006). Induction of Innate Immunity against Herpes Simplex Virus Type 2 Infection via Local Delivery of Toll-Like Receptor Ligands Correlates with Beta Interferon Production.. J. Virol. 80: 9943-9950 [Abstract] [Full Text]  
  • Ilyinskii, P. O., Wang, R., Balk, S. P., Exley, M. A. (2006). CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo. J. Virol. 80: 7146-7158 [Abstract] [Full Text]  
  • Montoya, C. J., Jie, H.-B., Al-Harthi, L., Mulder, C., Patino, P. J., Rugeles, M. T., Krieg, A. M., Landay, A. L., Wilson, S. B. (2006). Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells. J. Immunol. 177: 1028-1039 [Abstract] [Full Text]  
  • Svensson, A., Kaim, J., Mallard, C., Olsson, A., Brodin, E., Hokfelt, T., Eriksson, K. (2005). Neurokinin 1 Receptor Signaling Affects the Local Innate Immune Defense against Genital Herpes Virus Infection. J. Immunol. 175: 6802-6811 [Abstract] [Full Text]  
  • Carr, D. J. J., Tomanek, L., Silverman, R. H., Campbell, I. L., Williams, B. R. G. (2005). RNA-Dependent Protein Kinase Is Required for Alpha-1 Interferon Transgene-Induced Resistance to Genital Herpes Simplex Virus Type 2. J. Virol. 79: 9341-9345 [Abstract] [Full Text]  
  • Smiley, S. T., Lanthier, P. A., Couper, K. N., Szaba, F. M., Boyson, J. E., Chen, W., Johnson, L. L. (2005). Exacerbated Susceptibility to Infection-Stimulated Immunopathology in CD1d-Deficient Mice. J. Immunol. 174: 7904-7911 [Abstract] [Full Text]  
  • Svensson, A., Nordstrom, I., Sun, J.-B., Eriksson, K. (2005). Protective Immunity to Genital Herpes Simpex Virus Type 2 Infection Is Mediated by T-bet. J. Immunol. 174: 6266-6273 [Abstract] [Full Text]  
  • Gill, N., Rosenthal, K. L., Ashkar, A. A. (2005). NK and NKT Cell-Independent Contribution of Interleukin-15 to Innate Protection against Mucosal Viral Infection. J. Virol. 79: 4470-4478 [Abstract] [Full Text]  
  • Molesworth-Kenyon, S. J., Oakes, J. E., Lausch, R. N. (2005). A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen. J. Leukoc. Biol. 77: 552-559 [Abstract] [Full Text]  
  • Obar, J. J., Crist, S. G., Leung, E. K., Usherwood, E. J. (2004). IL-15-Independent Proliferative Renewal of Memory CD8+ T Cells in Latent Gammaherpesvirus Infection. J. Immunol. 173: 2705-2714 [Abstract] [Full Text]  
  • Nishimura, H., Yajima, T., Kagimoto, Y., Ohata, M., Watase, T., Kishihara, K., Goshima, F., Nishiyama, Y., Yoshikai, Y. (2004). Intraepithelial {gamma}{delta} T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2. J. Virol. 78: 4927-4930 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»