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Journal of Virology, September 2003, p. 10139-10146, Vol. 77, No. 18
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.18.10139-10146.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genetic Variability of Immunomodulatory Genes in Ectromelia Virus Isolates Detected by Denaturing High-Performance Liquid Chromatography

Gloria Ribas,1,{dagger} Jose Rivera,2,{dagger} Margarida Saraiva,2,{ddagger} R. Duncan Campbell,1 and Antonio Alcami2*

MRC UK HGMP Resource Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SB,1 Department of Medicine and Department of Pathology, Division of Virology, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom2

Received 19 August 2002/ Accepted 26 March 2003

The genetic variability of nine genes in 12 isolates and strains of ectromelia virus, which causes a smallpox-like disease (mousepox) in mice, was determined and allows for classification of ectromelia viruses. The low genetic variability suggests that evolutionary pressure maintains the activity of immunomodulatory genes in natural poxvirus infections.

* Corresponding author. Mailing address: Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Level 5, Box 157, Hills Rd., Cambridge CB2 2QQ, United Kingdom. Phone: 44 (1223) 763403. Fax: 44 (1223) 330158. E-mail: aa258{at}mole.bio.cam.ac.uk.

{dagger} Present address: Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain.

{ddagger} Present address: National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

Journal of Virology, September 2003, p. 10139-10146, Vol. 77, No. 18
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.18.10139-10146.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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