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Journal of Virology, September 2003, p. 10060-10070, Vol. 77, No. 18
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.18.10060-10070.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

T Cells Cause Acute Immunopathology and Are Required for Long-Term Survival in Mouse Adenovirus Type 1-Induced Encephalomyelitis

Martin L. Moore,1 Corrie C. Brown,2 and Katherine R. Spindler3*

Department of Genetics, Franklin College of Arts and Sciences,1 Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602,2 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 481093

Received 9 April 2003/ Accepted 17 June 2003

Infection of adult C57BL/6 (B6) mice with mouse adenovirus type 1 (MAV-1) results in dose-dependent encephalomyelitis. Utilizing immunodeficient mice, we analyzed the roles of T cells, T-cell subsets, and T-cell-related functions in MAV-1-induced encephalomyelitis. T cells, major histocompatibility complex (MHC) class I, and perforin contributed to acute disease signs at 8 days postinfection (p.i.). Acute MAV-1-induced encephalomyelitis was absent in mice lacking T cells and in mice lacking perforin. Mice lacking {alpha}/ß T cells had higher levels of infectious MAV-1 at 8 days, 21 days, and 12 weeks p.i., and these mice succumbed to MAV-1-induced encephalomyelitis at 9 to 16 weeks p.i. Thus, {alpha}/ß T cells were required for clearance of MAV-1. MAV-1 was cleared in mice lacking perforin, MHC class I or II, CD4+ T cells, or CD8+ T cells. Our results are consistent with a model in which either CD8+ or CD4+ T cells are sufficient for clearance of MAV-1. Furthermore, perforin contributed to MAV-1 disease but not viral clearance. We have established two critical roles for T cells in MAV-1-induced encephalomyelitis. T cells caused acute immunopathology and were required for long-term host survival of MAV-1 infection.

* Corresponding author. Mailing address: University of Michigan Medical School, 1150 W. Medical Center Dr., 6724 Medical Science Building II, Ann Arbor, MI 48109-0620. Phone: (734) 615-2727. Fax: (734) 764-3562. E-mail: krspin{at}umich.edu.

Journal of Virology, September 2003, p. 10060-10070, Vol. 77, No. 18
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.18.10060-10070.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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