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Journal of Virology, September 2003, p. 9710-9715, Vol. 77, No. 17
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.17.9710-9715.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Protective Efficacy of an AIDS Vaccine, a Single DNA Priming Followed by a Single Booster with a Recombinant Replication-Defective Sendai Virus Vector, in a Macaque AIDS Model

Akiko Takeda,1,2 Hiroko Igarashi,1 Hiromi Nakamura,2 Munehide Kano,2 Akihiro Iida,3 Takahiro Hirata,3 Mamoru Hasegawa,3 Yoshiyuki Nagai,2,4 and Tetsuro Matano1,2*

Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033,1 AIDS Research Center, National Institute of Infectious Diseases, Tokyo 208-0011,2 DNAVEC Research Inc., Tsukuba 305-0856,3 Toyama Institute of Health, Toyama 939-0363, Japan4

Received 23 April 2003/ Accepted 3 June 2003

We previously demonstrated the excellent protective efficacy of DNA priming followed by Gag-expressing Sendai virus (SeV) boosting (DNA prime/SeV-Gag boost vaccine) against a pathogenic simian-human immunodeficiency virus (SHIV89.6PD) infection in macaques. Here we show that we established a practical, safer AIDS vaccine protocol, a single DNA priming followed by a single booster with a recently developed replication-defective F deletion SeV-expressing Gag, and show its protective efficacy against SHIV89.6PD infections.

* Corresponding author. Mailing address: Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Phone: 81-3-5841-3409. Fax: 81-3-5841-3374. E-mail address: matano{at}m.u-tokyo.ac.jp.

Journal of Virology, September 2003, p. 9710-9715, Vol. 77, No. 17
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.17.9710-9715.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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