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Journal of Virology, August 2003, p. 9081-9083, Vol. 77, No. 16
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.16.9081-9083.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

TT Virus Loads and Lymphocyte Subpopulations in Children with Acute Respiratory Diseases

Fabrizio Maggi,1 Massimo Pifferi,2 Elena Tempestini,1 Claudia Fornai,1 Letizia Lanini,1 Elisabetta Andreoli,1 Marialinda Vatteroni,1 Silvano Presciuttini,1 Angelo Pietrobelli,3 Attilio Boner,3 Mauro Pistello,1 and Mauro Bendinelli1*

Virology Section and Retrovirus Center, Department of Experimental Pathology,1 Department of Pediatrics, University of Pisa, Pisa,2 Department of Pediatrics, University of Verona, Verona, Italy3

Received 10 February 2003/ Accepted 27 May 2003

TT virus (TTV) produces chronic plasma viremia in around 90% of healthy individuals of all ages and has, therefore, been proposed as a commensal human virus. We recently demonstrated that in children hospitalized for acute respiratory diseases high TTV loads were associated with severe forms of disease. Here, we report that in such children TTV loads showed an inverse correlation with the percentage of circulating total T and helper T cells and a direct correlation with the percentage of B cells. Thus, florid TTV replication might contribute to lymphocyte imbalances and, possibly, immunosuppressive effects, thus resembling related animal viruses.

* Corresponding author. Mailing address: Virology Section and Retrovirus Center, Department of Experimental Pathology, University of Pisa, via San Zeno 37, I-56127 Pisa, Italy. Phone: 39 050 221.3641. Fax: 39 050 221.3639. E-mail: bendinelli{at}biomed.unipi.it.

Journal of Virology, August 2003, p. 9081-9083, Vol. 77, No. 16
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.16.9081-9083.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Haramoto, E., Katayama, H., Ohgaki, S. (2008). Quantification and Genotyping of Torque Teno Virus at a Wastewater Treatment Plant in Japan. Appl. Environ. Microbiol. 74: 7434-7436 [Abstract] [Full Text]  
  • Maggi, F., Andreoli, E., Lanini, L., Fornai, C., Vatteroni, M., Pistello, M., Presciuttini, S., Bendinelli, M. (2005). Relationships between Total Plasma Load of Torquetenovirus (TTV) and TTV Genogroups Carried. J. Clin. Microbiol. 43: 4807-4810 [Abstract] [Full Text]  


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